IMMUNOLOGICAL, BIOCHEMICAL, AND MOLECULAR STUDIES ON EPITHELIAL OVARIAN CANCER
IMMUNOLOGICAL, BIOCHEMICAL, AND MOLECULAR STUDIES ON EPITHELIAL OVARIAN CANCER
批准号:
6237133
负责人:
KENNETH O LLOYD
金额:
$15.34万
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-02-01 至 1998-09-29
关键词:
antitumor antibody binding proteins biomarker blood group antigens carbohydrates epithelium exopeptidase female folate human subject immunocytochemistry laboratory mouse molecular oncology monoclonal antibody mucins neoplasm /cancer immunology neoplastic transformation ovary neoplasms protein sequence protein structure function tissue /cell culture tumor antigens women's health
中文摘要
该项目的主要目标是鉴定抗原的特征
英文摘要
The major goal of this Project are to identify antigens characteristics
of epithelial ovarian cancer (EOC) using mouse monoclonal antibodies
(mAbs) and to study some aspects of the biology of ovarian epithelium and
its malignant transformation. The antigens detected by the mAbs will be
characterized using biochemical and molecular approaches. An important
aim will be to identify mAbs that are suitable for use in clinical trials
involving EOC. Among mAbs to be studied are mAb MX35 (detecting a 95,000
glycoprotein), mAbs VK-5, 6, and 7 (detecting the MUC-1 mucin epitope),
mAb MW 207 (detecting folate-binding protein) and mAb VK-8 (detecting a
novel EOC antigen). This Project will also test chimeric and humanized
versions of an anti-blood group Le antibody for their specificity and
other parameters. Another goal will be to use various mAbs to detect
markers related to the progression of normal ovarian epithelium to EOC
and markers suitable for the classification of ovarian tumors. Three
types of antigens will be examined: 1) blood group antigens, 2)
ectopeptidases, and 3) mucins. Mucins will be studied in more detail
using biochemical and molecular techniques in order to understand the
role played by mucins in EOC. Also, novel methods for the analysis of
the carbohydrate content of glycoproteins and mucins will be developed.
The accomplishment of theses goals will provide new reagents for the
diagnosis and therapy of EOC and will lead to an understanding of the
antigenic changes associated with the malignant transformation of normal
ovarian epithelium, tumor progression, and the biological behavior of
ovarian tumors.
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IMMUNOLOGICAL, BIOCHEMICAL, AND MOLECULAR STUDIES ON EPITHELIAL OVARIAN CANCER
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批准号:6334956
-
项目类别:
-
资助金额:$26.78万
-
财政年份:2000
-
负责人:KENNETH O LLOYD
-
依托单位:
CORE--CELL CULTURE, ANTIBODY, AND BIOCHEMISTRY CORE
-
批准号:6334958
-
项目类别:
-
资助金额:$26.78万
-
财政年份:2000
-
负责人:KENNETH O LLOYD
-
依托单位:
IMMUNOLOGICAL, BIOCHEMICAL, AND MOLECULAR STUDIES ON EPITHELIAL OVARIAN CANCER
-
批准号:6203170
-
项目类别:
-
资助金额:$26.78万
-
财政年份:1999
-
负责人:KENNETH O LLOYD
-
依托单位:
CORE--CELL CULTURE, ANTIBODY, AND BIOCHEMISTRY CORE
-
批准号:6203172
-
项目类别:
-
资助金额:$26.78万
-
财政年份:1999
-
负责人:KENNETH O LLOYD
-
依托单位:
CORE--CELL CULTURE, ANTIBODY, AND BIOCHEMISTRY CORE
-
批准号:6102613
-
项目类别:
-
资助金额:$26.78万
-
财政年份:1998
-
负责人:KENNETH O LLOYD
-
依托单位:
IMMUNOLOGICAL, BIOCHEMICAL, AND MOLECULAR STUDIES ON EPITHELIAL OVARIAN CANCER
-
批准号:6102611
-
项目类别:
-
资助金额:$26.78万
-
财政年份:1998
-
负责人:KENNETH O LLOYD
-
依托单位:
CORE--MONOCLONAL ANTIBODIES AND LABORATORY SUPPORT
-
批准号:6237134
-
项目类别:
-
资助金额:$15.34万
-
财政年份:1997
-
负责人:KENNETH O LLOYD
-
依托单位:
CARBOHYDRATE-BASED TUMOR VACCINES
-
批准号:2733247
-
项目类别:
-
资助金额:$22.16万
-
财政年份:1996
-
负责人:KENNETH O LLOYD
-
依托单位:
CARBOHYDRATE-BASED TUMOR VACCINES
-
批准号:6173066
-
项目类别:
-
资助金额:$23.41万
-
财政年份:1996
-
负责人:KENNETH O LLOYD
-
依托单位:
CARBOHYDRATE-BASED TUMOR VACCINES
-
批准号:2443272
-
项目类别:
-
资助金额:$21.57万
-
财政年份:1996
-
负责人:KENNETH O LLOYD
-
依托单位:
CARBOHYDRATE-BASED TUMOR VACCINES
-
批准号:2115107
-
项目类别:
-
资助金额:$20.84万
-
财政年份:1996
-
负责人:KENNETH O LLOYD
-
依托单位:
CARBOHYDRATE-BASED TUMOR VACCINES
-
批准号:2895596
-
项目类别:
-
资助金额:$22.77万
-
财政年份:1996
-
负责人:KENNETH O LLOYD
-
依托单位:
GANGLIOSIDE BIOSYNTHESIS IN TUMOR CELLS
-
批准号:2101434
-
项目类别:
-
资助金额:$25.03万
-
财政年份:1993
-
负责人:KENNETH O LLOYD
-
依托单位:
GANGLIOSIDE BIOSYNTHESIS IN TUMOR CELLS
-
批准号:2101432
-
项目类别:
-
资助金额:$23.71万
-
财政年份:1993
-
负责人:KENNETH O LLOYD
-
依托单位:
GANGLIOSIDE BIOSYNTHESIS IN TUMOR CELLS
-
批准号:2101433
-
项目类别:
-
资助金额:$24.47万
-
财政年份:1993
-
负责人:KENNETH O LLOYD
-
依托单位:
GANGLIOSIDE BIOSYNTHESIS IN TUMOR CELLS
-
批准号:2429785
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项目类别:
-
资助金额:$25.57万
-
财政年份:1993
-
负责人:KENNETH O LLOYD
-
依托单位:
GANGLIOSIDE BIOSYNTHESIS IN TUMOR CELLS
-
批准号:3204185
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项目类别:
-
资助金额:$20.03万
-
财政年份:1993
-
负责人:KENNETH O LLOYD
-
依托单位:
INTRACELLULAR TRAFFICKING AND RECYCLING OF GLYCOLIPIDS
-
批准号:2098217
-
项目类别:
-
资助金额:$19.89万
-
财政年份:1992
-
负责人:KENNETH O LLOYD
-
依托单位:
INTRACELLULAR TRAFFICKING AND RECYCLING OF GLYCOLIPIDS
-
批准号:3201816
-
项目类别:
-
资助金额:$18.94万
-
财政年份:1992
-
负责人:KENNETH O LLOYD
-
依托单位:
INTRACELLULAR TRAFFICKING AND RECYCLING OF GLYCOLIPIDS
-
批准号:2098218
-
项目类别:
-
资助金额:$20.78万
-
财政年份:1992
-
负责人:KENNETH O LLOYD
-
依托单位:
海外基金