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EVALUATION OF DOMINANTLY-ACTING RAS ONCOGENES

EVALUATION OF DOMINANTLY-ACTING RAS ONCOGENES
对起主导作用的 RAS 癌基因的评估
批准号:
2668028
负责人:
ERIC J. STANBRIDGE
金额:
$25.25万
依托单位国家:
美国
项目类别:
财政年份:
1996
资助国家:
美国
项目状态:
已结题
起止时间:
1996-05-01 至 2001-02-28

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中文摘要
翻译
说明:本提案的目的是确定是否维护
英文摘要
DESCRIPTION: The aim of this proposal is to determine whether maintenance of the human cancer cell tumorigenic phenotype depends on the continued presence of activated ras oncogenes. Three different experimental protocols are proposed: 1) activated ras alleles will be inactivated by targeted homologous recombination, or by the expression of a doubly mutant ras dominant negative allele; 2) dominant negative alleles of proteins in the 2 well characterized ras signalling pathways will be used to selectively disrupt each pathway; and 3) ras antisense oligonucleotides will be used to modify the in vitro growth properties and tumorigenic potential of human tumor cells containing activated ras alleles. The human tumor cells used for these experiments are heterozygous for activating mutations in H-, K- or N-ras. Assays of genetically modified or oligonucleotide-treated cells will include biochemical examination of ras and ras-dependent signalling pathways, growth and morphology in vitro, and tumor formation in mice.
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Single Cell Analysis of Cross Talk Among Kinase Pathways
  • 批准号:
    7178789
  • 项目类别:
  • 资助金额:
    $5.5万
  • 财政年份:
    2005
  • 负责人:
    ERIC J. STANBRIDGE
  • 依托单位:
Single Cell Analysis of Cross Talk Among Kinase Pathways
  • 批准号:
    7324436
  • 项目类别:
  • 资助金额:
    $5.39万
  • 财政年份:
    2005
  • 负责人:
    ERIC J. STANBRIDGE
  • 依托单位:
Single Cell Analysis of Cross Talk Among Kinase Pathways
  • 批准号:
    6872729
  • 项目类别:
  • 资助金额:
    $31.16万
  • 财政年份:
    2005
  • 负责人:
    ERIC J. STANBRIDGE
  • 依托单位:
Single Cell Analysis of Cross Talk Among Kinase Pathways
  • 批准号:
    7055189
  • 项目类别:
  • 资助金额:
    $4.5万
  • 财政年份:
    2005
  • 负责人:
    ERIC J. STANBRIDGE
  • 依托单位:
海外基金