NEUROCHEMISTRY OF INJURY-INDUCED CORTICAL PLASTICITY

损伤引起的皮质可塑性的神经化学

• 批准号: 2708730
• 负责人: James D Churchill
• 金额: $ 1.77万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-13 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2708730
• 关键词: Saimiri; electrophysiology; implant; microdialysis; nerve injury; neural plasticity; neurochemistry; neurosurgery; somesthetic sensory cortex

DESCRIPTION (Adapted from applicant's abstract): Within the past two decades, our meager understanding of how the adult brain can change has grown exponentially. The accessibility of somotosensory cortical areas and the highly reliable central representation of the body surface have provided a particularly fertile model by which to study adult neural plasticity. Manipulations of afferent stimulation patterns are accompanied by (now) predictable alterations in the topographic representation of the dermal surface. It is likely that many of the mechanisms by which somatosensory areas "learn" new responses after nerve injury are evolutionarily conserved in other brain areas as well. These changes can be beneficial or detrimental in nature and may manifest themselves as the ability to consolidate memory, or in the progression of a pathological disease. While injury induced reorganization in the somatosensory cortex has been extensively studied the mechanisms responsible for cortical plasticity have not been fully elucidated. In the present application, it is proposed that the neurochemical changes that occur during cortical reorganization be monitored and then compared to any neurochemical changes that might occur in response to deprivation alone. Such a subtractive analysis permits the identification of the neurochemical changes that are causal and those that are epiphenomenal.

描述(改编自申请人的摘要)：在过去两年内 几十年来，我们对成人大脑如何改变的微不足道的理解 成倍增长。躯体感觉皮层区域的可达性和 高度可靠的体表中心表示提供了 这是一种研究成人神经可塑性的特别有效的模型。 传入刺激模式的操作伴随着(现在) 可预见的真皮地形图的变化 浮出水面。很可能躯体感觉的许多机制 神经损伤后“学习”新反应的区域进化上是保守的 在其他大脑区域也是如此。这些变化可能是有益的或 在性质上是有害的，并可能表现为 巩固记忆，或在病理性疾病的发展过程中。而当 损伤诱导的躯体感觉皮质的重组已经被 广泛研究了导致皮质可塑性的机制 还没有完全阐明。在本申请中，建议 在皮质重组过程中发生的神经化学变化是 监测并与可能发生的任何神经化学变化进行比较 仅仅是对剥夺的反应。这样的减法分析允许 识别引起的神经化学变化和那些 都是超凡的。