FRAP AND THE RAPAMYCIN SENSITIVE SIGNALING PATHWAY

FRAP 和雷帕霉素敏感信号通路

基本信息

  • 批准号:
    2877671
  • 负责人:
  • 金额:
    $ 10万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1998
  • 资助国家:
    美国
  • 起止时间:
    1998-09-30 至 1999-05-31
  • 项目状态:
    已结题

项目摘要

The effects of mitogens on cell proliferation are mediated by increases in both transcription and translation. Much is known about the signaling pathways that link extracellular signals to the nucleus, but less is known about the precise mechanisms involved in the regulation of protein synthesis. Recent studies by a number of investigators have shown that protein translation is regulated by a signaling pathway that is inhibited by the immunosuppressant, rapamycin. Rapamycin in a complex with its binding protein, FKBP-12, binds to a protein termed FRAP (FKBP12-rapamycin-associated protein). By an unknown mechanism the binding of FKBP12-rapamycin to FRAP interferes with signaling initiated by receptor activation of phosphatidylinositol-3-kinase (PI3K). The most well characterized effects of rapamycin are inhibition of p70S6 kinase (p70S6K), a regulator of translational initiation, and decreased phosphorylation of 4E-BP1, a regulator of initiation factor eIF-4E. FRAP is related in primary amino acid sequence to the family of lipid kinases that includes PI3K, however, it is thought to be a protein kinase. Potential substrates for FRAP are 4E-BP1 and regulators of protein phosphatase activity. This application is aimed at investigating several aspects of FRAP. In Aim I, the function of FRAP will be investigated through the identification of novel substrates. The relationship of these substrates to the regulation of p70S6K and 4E- BP1 will be studied. In Aim II, the role of the domain of FRAP that binds FKBP12-rapamycin will be studied. In Aim III, novel proteins that associate with FRAP in a multi-protein complex will be purified and characterized. In Aim IV, the relationship of FRAP to the regulation of protein phosphatases will be studied. By understanding the detailed biochemical properties of FRAP, fundamental questions of how protein translation is coupled to cell cycle progression will be answered.
有丝分裂原对细胞增殖的影响是通过增加介导的

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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JIE CHEN其他文献

JIE CHEN的其他文献

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{{ truncateString('JIE CHEN', 18)}}的其他基金

Dose analysis for translating animal based vibrational force study for accelerating orthodontic tooth movement to clinic
将基于动物的振动力研究加速正畸牙齿移动的剂量分析转化为临床
  • 批准号:
    10596536
  • 财政年份:
    2022
  • 资助金额:
    $ 10万
  • 项目类别:
Dose analysis for translating animal based vibrational force study for accelerating orthodontic tooth movement to clinic
将基于动物的振动力研究加速正畸牙齿移动的剂量分析转化为临床
  • 批准号:
    10362972
  • 财政年份:
    2022
  • 资助金额:
    $ 10万
  • 项目类别:
Evaluation of Canine Retraction Strategies
犬类回缩策略的评估
  • 批准号:
    7799134
  • 财政年份:
    2009
  • 资助金额:
    $ 10万
  • 项目类别:
Evaluation of Canine Retraction Strategies
犬类回缩策略的评估
  • 批准号:
    8020947
  • 财政年份:
    2009
  • 资助金额:
    $ 10万
  • 项目类别:
Evaluation of Canine Retraction Strategies
犬类回缩策略的评估
  • 批准号:
    8220980
  • 财政年份:
    2009
  • 资助金额:
    $ 10万
  • 项目类别:
Evaluation of Canine Retraction Strategies
犬类回缩策略的评估
  • 批准号:
    7650664
  • 财政年份:
    2009
  • 资助金额:
    $ 10万
  • 项目类别:
Development of Force Based Orthodontic Appliances
基于力的正畸矫治器的开发
  • 批准号:
    7106950
  • 财政年份:
    2006
  • 资助金额:
    $ 10万
  • 项目类别:
FINITE ELEMENT ANALYSIS OF HUMAN MANDIBLE W/ & W/OUT IMPLANT
人下颌骨的有限元分析
  • 批准号:
    5225403
  • 财政年份:
  • 资助金额:
    $ 10万
  • 项目类别:

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