ORGANOTIN BIOCIDES

有机锡化合物是杀生剂的一大类，用途包括 马铃薯枯萎病对海洋防污组分的防护 油漆。我们建议从结构和光谱上合成 表征新的有机锡化合物，并对其杀生活性进行评估。 我们将通过合成具有特殊活性的化合物 功能取代基，如离子载体、二茂铁基。综合将会 使用在PI实验室中建立良好的工艺。 将合成多聚体结合的有机锡来改变锡的速率 释放，这是安全使用有机锡的一个关键方面。系统化 已知的有机锡杀菌剂(如Ph3SnC1)的替代品将是 执行以修改他们的活动和基于计算机的结构/反应性 将开发模型来评估活动，然后设计新的 活跃性增强的结构群。有机锡的广泛使用 导致河口和相关水域以及食物中锡的污染 链(养殖鱼和软体动物)。由于一种分解模式 有机锡被认为是光化学的，我们将研究 土壤环境中已知的杀菌剂的光化学，例如包裹在 粘土，其中可能观察到与正常溶液不同的结果 光化学。这样的研究可以导致新材料的配方 更好、更安全、更具生物降解性。因为有机锡也是 据报道，作为抗肿瘤药物，所有系统都将进行评估 对于这种活性以及杀生性能。 学生培训将涉及化学和微生物成分， 在指导下介绍光谱和，并最终自行使用 分析技术，如核磁共振，高效液相色谱，气相色谱/质谱学和一般 指导安全和合乎道德的生物医学研究。

Organotin compounds are a major class of biocide, with uses ranging from protection against potato blight to anti-fouling components of marine paints. We propose to synthesize, structurally and spectroscopically characterize, and evaluate for biocidal activity, new organotin compounds. We shall synthesize compounds that promise special activity by virtue of functional substituents, e.g. ionophores, ferrocenyl. The synthesis will be using processes well-established in the laboratory of the PI. Polymerbound organotins will be synthesized to modify the rate of tin release, a crucial aspect of the safe use of organotins. Systematic substitutions into known organotin biocides (e.g. Ph3SnC1) will be performed to modify their activity, and computer-based structure/reactivity models will be developed to evaluate activity, and then to design new structural groupings with enhanced activity. Widespread use of organotins results in tin contamination of estuarine and related waters, and the food chain (farm reared fish and molluscs). Since one mode of decomposition of organotins is thought to be photochemical, we shall study the photochemistry of known biocides in soil environments, e.g. encapsulated in clays, where different results maybe observed compared to normal solution photochemistry. Such studies can lead to formulation of new materials with better, safer, biodegradation properties. Since organotins are also reported to be useful as anti-tumor drugs, all systems will be evaluated for such activity along with biocidal properties. Student training will involve chemical and microbiological components, supervised introduction to, and finally self-use of, spectroscopic and analytical techniques such as NMR, HPLC, GC/mass spectroscopy, and general mentoring in safe and ethical biomedical research.