Safe Organotin Materials

安全的有机锡材料

• 批准号: 7282280
• 负责人: KEITH H PANNELL
• 金额: $ 14.04万
• 依托单位: UNIVERSITY OF TEXAS EL PASO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7282280
• 关键词: Safe; Organotin; Materials

Organotin compounds (OTs) are widely used in many societal processes and have recently been identified in the blood of > 80% of the US population where they can have a profound negative impact upon human natural killer cell (NKC) function. We will address this critical health-related problem. Using SCORE support we have shown that the simple structural motif of an S or O atom within the molecular structure of certain OTs (permitting an intramolecular self-association between the Sn and S(O)) dramatically reduces the impact of the OT upon the NKCs and augments biological targetting. We propose to synthesize OTs containing 2 and 3 S(O)(N)-containing aryl and alkyl ligands to augment this protection including 14C/fluorophore tagged species for biochemical tracking. This program of synthesis will be augmented by an antibacterial assessment that has proven very indicative of OT structure-reactivity relationships. A collaborative evaluation of the OT impact upon NKCs with Professor Margaret Whalen (Tennessee State University) will be continued. In tandem with this program of synthesis and biological evaluation we shall test the new materials to assess their capacity to provide the societal uses that make tin the element with the largest number of individual derivatives used in modern society. Thus, e.g., polymer formation, curing and stabilization will be evaluated using the appropriate and recognized techniques to show that the weak intramolecular Sn.S(O)(N) interactions, while enough to have a profound solid-state structural and biological impact will not remove their industrial roles. In collaboration with Dr. Renato Aguilera (U. T. El Paso) we have preliminary results that demonstrate the presence of the intramolecular Sn..S motif does not remove the capacity of selected OTs to inhibit the growth of uterine cancer HeLa (GFP) cells. Since there is much interest in OTs as anti-tumor agents this result is most promising, i.e. excellent anti-tumor activity with significantly reduced anti-HKC activity. Also, a recent report on the efficacy of OTs as anti-parasitics against Leishmania donovani, will be evaluated in collaboration with Dr. Rosa Maldonado (U. T. El Paso) since in our region, SW-USA with large immigration from Central/South America where such parasites are endemic, this is a problem of growing concern. Letters agreeing to the collaborations are attached.

有机锡化合物（OTs）广泛应用于许多社会过程中，并且最近已被鉴定 超过80%的美国人的血液中，它们可能对人类产生深远的负面影响。 自然杀伤细胞（NKC）功能。我们将解决这一与健康有关的关键问题。使用SCORE支持 我们已经表明，某些分子结构中的S或O原子的简单结构基序 OTs（允许Sn和S（O）之间的分子内自缔合）显著降低了 OT对NKC的影响，并增强生物靶向。我们建议合成OT 含有2和3个含S（O）（N）的芳基和烷基配体以增强这种保护，包括 14 C/荧光团标记的物种用于生化追踪。这一综合方案将得到加强， 抗菌评估已被证明非常指示OT结构-反应性关系。一 与玛格丽特·惠伦教授（田纳西州）合作评估OT对NKC的影响 大学将继续。在这个合成和生物学评价计划的同时，我们将测试 新材料，以评估他们的能力，提供社会用途，使锡的元素与 现代社会中使用的最多的个人衍生品。因此，例如，聚合物形成、固化和 将使用适当的和公认的技术来评估稳定性，以表明薄弱的 分子内Sn.S（O）（N）相互作用，同时足以具有深刻的固态结构和生物学性质。 影响不会消除它们的工业作用。 Renato Aguilera博士（美国）T.埃尔帕索），我们有初步的结果表明， 分子内Sn的存在。S基序并不消除所选OT抑制细胞凋亡的能力。 子宫癌HeLa（GFP）细胞的生长。由于人们对OT作为抗肿瘤剂很感兴趣， 结果是最有希望的，即优异的抗肿瘤活性，同时显著降低的抗HKC活性。还有，一 最近关于OT作为抗杜氏利什曼原虫的抗寄生虫药的疗效的报告，将在 与Rosa马尔多纳多博士（美国T.埃尔帕索），因为在我们的地区，西南-美国与大量移民 从这种寄生虫流行的中美洲/南美洲，这是一个日益受到关注的问题。字母 同意合作的文件附后。