PROTON NMR STRATEGIES TO ASSESS ISCHEMIC HEART DISEASE

评估缺血性心脏病的质子核磁共振策略

• 批准号: 2693372
• 负责人: JAN A DEN HOLLANDER
• 金额: $ 32.95万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2693372
• 关键词: cardiography; cineangiocardiography; clinical research; heart contraction; heart motion; human subject; myocardial infarction; myocardial ischemia /hypoxia; myocardium; nuclear magnetic resonance spectroscopy; regeneration

DESCRIPTION (Adapted from Applicant's Abstract): Following a myocardial ischemic event, a number of changes take place in the affected part of the myocardium. The center of the ischemic region may be irreversibly damaged, leading to cell death and necrosis. Surrounding this central infarct zone is a region at risk, where the myocardium has been affected by the ischemic event but, with proper intervention, still has the potential for recovery. Information about the extent of the viable region is essential for diagnosis, prognosis, and the planning of appropriate intervention. The applicants proposed to differentiate irreversibly damaged (IR), ischemically insulted but viable (IV), and hibernating (H) myocardium from normal tissue non-involved and without contrast agents using nuclear magnetic resonance (NMR) imaging and spectroscopic techniques. These techniques include: function cine imaging to identify the contractile properties of the myocardium; magnetization transfer contrast imaging to identify IR tissue; T2-weighted turbo spin echo imaging to identify IR and IV tissue; and water-suppressed lipid imaging and 1H spectroscopic imaging to identify IV. Hibernating myocardium is identified by lipid imaging in conjunction with abnormal contraction. Patients who have had recent infarcts or have chronic stable ischemic disease or have ischemic cardiomyopathies have varying degrees of IR, IV, and H. By studying these patients and following up where appropriate, the applicants proposed to confirm the identification of these different tissues. In addition, the MTC effect is little understood in the heart. Using a canine model of ischemia, the applicants proposed to follow the development of the MTC effect and compare it to both ex vivo. images and histology. By using these approaches together with the high quality functional images that can be generated by proton nuclear magnetic resonance cardiac imaging, the type and extent of ischemic damage should be assessable. Once accomplished successfully, such information derived clinically could have an impact on the future of the practice of cardiology.

描述(改编自申请者摘要)：跟随心肌 脑缺血事件后，大脑的受累部位会发生一些变化。 心肌。缺血区的中心可能受到不可逆转的损害， 导致细胞死亡和坏死。围绕着这个中央梗死区 是心肌受到缺血影响的高危区域吗？ 但在适当的干预下，仍有复苏的潜力。 有关可生存区域范围的信息对于 诊断、预后和适当干预的计划。这个 申请人建议区分不可逆性损伤(IR)，缺血 隔离但存活的(IV)和冬眠(H)正常组织的心肌 非受累和不含造影剂的核磁共振 (核磁共振)成像和光谱技术。这些技术包括： 功能电影成像以识别血管的收缩特性 心肌；磁化传递对比成像识别IR组织； T2加权快速自旋回波成像识别IR和IV组织；以及 水抑制脂质成像和~1H光谱成像鉴定IV。 冬眠心肌的识别是通过脂质成像结合 异常收缩。近期发生脑梗塞或患有慢性心肌梗塞的患者 稳定性缺血性疾病或有缺血性心肌病有不同 IR、IV和H的程度通过研究这些患者并在哪里进行随访 适当的，申请人建议确认这些身份证明 不同的组织。此外，人们对MTC效应还知之甚少 心。使用犬类缺血模型，申请者建议遵循 MTC效应的发展，并将其与体外实验进行比较。图像 和组织学。通过将这些方法与高质量的 可由质子核磁共振产生的功能图像 心脏成像，缺血性损害的类型和程度应该是 可评估的。一旦成功完成，这些信息就会派生出来 临床上可能会对心脏病学的未来实践产生影响。