CORE PROJECT 1 SPECTROSCOPIC METHODS

核心项目 1 光谱方法

• 批准号: 6123437
• 负责人: JAN A DEN HOLLANDER
• 金额: $ 18.19万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6123437
• 关键词: Mammalia; animal tissue; biomedical resource; cardiovascular system; health care; lipids; magnetic resonance imaging; technology /technique

During myocardial ischemia, oxidative metabolism is reduced and fatty acids and triglycerides accumulate within the myocardial cell. The fatty acids and related substances, such as fatty acylcarnitines, are amphophilic and can lead to cell membrane destruction. Magnetic resonance methods can assess the concentration of lipids (generally triglycerides) within the myocardium. The observation of lipids within the myocardium is postulated to indicate viability. Various pharmacological interventions are used to evaluate their effect on myocardial lipid accumulation in control and during myocardial ischemic insults. Surface coils placed on the epicardium are used to interrogate the myocardial lipid content in a 4.7T Bruker Biospec 40cm bore system in canine models. It is anticipated that in the last years of this RO1, patients with MI, both reperfused and non-reperfused, will be studied in the 4.1T MR system to determine the relationship between myocardial lipid content and high energy phosphate metabolism.

在心肌缺血期间，氧化代谢减少， 脂肪酸和甘油三酯在心肌细胞内积累。 脂肪酸和相关物质，如脂肪酰基肉毒碱， 是两亲性的，并可导致细胞膜破坏。 磁 共振方法可以评估脂质的浓度（通常 甘油三酯）。 血脂观察 假设心肌内的存活率指示存活力。 各种 药物干预用于评估其对 对照组和心肌缺血期间的心肌脂质蓄积 缺血性损伤 放置在心外膜上的表面线圈用于 在4.7T Bruker Biospec 40 cm 犬模型中的钻孔系统。 预计在过去的一年里， 年的RO1，MI患者，再灌注和 非再灌注，将在4.1T MR系统中进行研究，以确定 心肌脂质含量与高能量的关系 磷酸盐代谢