CORE PROJECT 1 SPECTROSCOPIC METHODS

在心肌缺血期间，氧化代谢降低， 脂肪酸和甘油三酯在心肌细胞内积累。 脂肪酸和相关物质，如脂肪酰卡尼汀， 是两亲性的，会导致细胞膜的破坏。磁性 共振法可以评估脂类的浓度(一般 甘油三酯)。血脂的观察 在心肌内被认为是可存活的。五花八门 药理干预被用来评估它们对 对照组和心肌梗死期间的心肌脂质积聚 对缺血儿的侮辱。放置在心外膜上的表面线圈用于 4.7T Bruker Biospec 40 cm心肌脂质含量测定 犬模型中的内孔系统。预计在最后一年， 多年的RO1，心肌梗死患者，无论是再灌流还是 无再灌注，将在4.1T磁共振系统中进行研究，以确定 心肌脂含量与高能的关系 磷酸盐代谢。

During myocardial ischemia, oxidative metabolism is reduced and fatty acids and triglycerides accumulate within the myocardial cell. The fatty acids and related substances, such as fatty acylcarnitines, are amphophilic and can lead to cell membrane destruction. Magnetic resonance methods can assess the concentration of lipids (generally triglycerides) within the myocardium. The observation of lipids within the myocardium is postulated to indicate viability. Various pharmacological interventions are used to evaluate their effect on myocardial lipid accumulation in control and during myocardial ischemic insults. Surface coils placed on the epicardium are used to interrogate the myocardial lipid content in a 4.7T Bruker Biospec 40cm bore system in canine models. It is anticipated that in the last years of this RO1, patients with MI, both reperfused and non-reperfused, will be studied in the 4.1T MR system to determine the relationship between myocardial lipid content and high energy phosphate metabolism.