ANTIBODIES TO NEW AMPLIFIED BREAST CANCER GENE PRODUCTS

描述：(改编自申请者的摘要)他们的目标是发展 新的，强大的免疫组织化学测试，预测治疗的反应 乳腺癌。他们正在研制针对一种新的放大乳房的抗体 他们发现的癌症基因产物，被扩增和 在10%的原发乳腺癌中过度表达。该基因编码一种 凋亡抑制因子，并可能影响肿瘤细胞对 通过细胞凋亡机制起作用的治疗方法。对此的抗体被放大 基因产物在扩增的组织切片中显示肿瘤特异性染色 肿瘤。他们将直接测试这种基因的过度表达是否会影响 通过体外功能试验对治疗的反应并开始检查 临床注解的肿瘤库。针对其他新的放大乳房的抗体 癌症基因也将被开发和测试。 建议的商业应用：不可用

DESCRIPTION: (Adapted from the applicant's abstract) Their goal is to develop new, robust immuohistochemistry tests that predict response to treatments in breast cancer. They are developing antibodies to a novel amplified breast cancer gene product which they discovered and that is amplified and overexpressed in 10 percent of primary breast cancers. This gene encodes an inhibitor of apoptosis and is likely to influence tumor cell response to treatments that act by an apoptotic mechanism. Antibodies to this amplified gene product exhibit tumor-specific staining in tissue sections from amplified tumors. They will direct test whether overexpression of this gene affects response to treatments by in vitro functional tests and begin examination of clinically annotated tumor banks. Antibodies to other novel amplified breast cancer genes will also be developed and tested. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE