用于全细胞肿瘤疫苗的工程调理素-猫眼课题宝

用于全细胞肿瘤疫苗的工程调理素

批准号：

6143080

负责人：

ANDREW H SEGAL

金额：

$20.4万

依托单位：

GENITRIX, LLC

依托单位国家：

美国

项目类别：

财政年份：

2000

资助国家：

美国

项目状态：

已结题

起止时间：

2000-03-01 至 2001-10-31

来源：

https://reporter.nih.gov/project-details/6143080

关键词：

cytotoxic T lymphocyte glycosylphosphatidylinositols helper T lymphocyte laboratory mouse molecular cloning natural killer cells neoplasm /cancer vaccine opsonin protein engineering tissue /cell culture transfection vaccine development

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英文摘要

A number of strategies are under development by various groups for the creation of therapeutic tumor vaccines using gene transfer in autologous tumor cells. However, gene transfer entails a number of technical problems that limit both the clinical utility and commercial viability of such vaccines. As an alternative, this project will identify a chimeric GPI-linked molecule that improves the efficiency of events in the afferent limb of the immune response. The utility of this molecule in the creation of tumor vaccines will be tested in mouse models. PROPOSED COMMERCIAL APPLICATIONS: Novel technology for cancer vaccines

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