ENGINEERED OPSONINS FOR WHOLE CELL TUMOR VACCINES

许多策略正在由不同的小组开发，用于使用自体肿瘤细胞中的基因转移来创建治疗性肿瘤疫苗。然而，基因转移带来了许多技术问题，限制了这种疫苗的临床应用和商业可行性。作为一种替代方案，该项目将确定一种嵌合GPI连接的分子，该分子可以提高免疫反应传入肢体中事件的效率。将在小鼠模型中测试这种分子在创建肿瘤疫苗中的效用。拟议的商业应用：癌症疫苗的新技术

A number of strategies are under development by various groups for the creation of therapeutic tumor vaccines using gene transfer in autologous tumor cells. However, gene transfer entails a number of technical problems that limit both the clinical utility and commercial viability of such vaccines. As an alternative, this project will identify a chimeric GPI-linked molecule that improves the efficiency of events in the afferent limb of the immune response. The utility of this molecule in the creation of tumor vaccines will be tested in mouse models. PROPOSED COMMERCIAL APPLICATIONS: Novel technology for cancer vaccines