DNA Vaccines for Anthrax: Targeting Afferent Immunity

描述（由申请人提供）：B。炭疽是国家生物防御的主要关注的病原体。DNA疫苗在这方面具有许多潜在的优势。然而，它们通常仅引起适度的免疫应答。我们将生产炭疽的候选DNA疫苗，其中包含一种专有技术，该技术针对免疫系统的传入分支，显着放大免疫反应。该技术还可以加速响应。我们将在非感染性小鼠模型中测试我们的疫苗。

DESCRIPTION (provided by the applicant): B. anthracis is a pathogen of major concern for national biodefense. DNA vaccines have a number of potential advantages in this context. However, they often elicit only modest immune responses. We will generate candidate DNA vaccines for anthrax that incorporate a proprietary technology which targets the afferent limb of the immune system, markedly amplifying the immune response. The technology may also accelerate the response. We will test our vaccines in non-infectious mouse models.