CHIMERIC CELL-SURFACE CYTOKINE FOR TUMOR VACCINES

描述：(改编自申请人的摘要) 各个团体正在制定战略，以创建 自体肿瘤基因转移治疗性肿瘤疫苗 细胞。然而，基因转移带来了一些技术问题， 限制这类疫苗的临床用途和商业可行性。 作为替代方案，该项目将生成一个与GPA关联的原型 一种分子，它提高了脑干传入肢体的活动效率。 免疫反应。这种分子在创造宇宙中的作用 肿瘤疫苗将在小鼠模型中进行测试。 建议的商业应用：不可用

DESCRIPTION: (Adapted from the applicant's abstract) A number of strategies are under development by various groups for the creation of therapeutic tumor vaccines using gene transfer into autologous tumor cells. However, gene transfer entails a number of technical problems that limit both the clinical utility and commercial viability of such vaccines. As an alternative, this project will generate a prototype GPA-linked molecule that improves the efficiency of events in the afferent limb of the immune response. The utility of this molecule in the creation of tumor vaccines will be tested in mouse models. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE