WHOLE CELL TUMOR VACCINES BASED ON GPI LINKED MOLECULE

描述：(改编自申请人的摘要)许多策略是 正在由不同的团体开发用于创造治疗性肿瘤 使用基因转移到自体细胞的疫苗。然而，基因转移 需要一些技术问题，这些问题限制了临床应用和 此类疫苗的商业可行性。作为替代方案，该项目将 产生嵌合的糖基磷脂酰肌醇连接的分子 促进免疫反应传入肢体的早期活动。这个 这种分子在创造肿瘤疫苗中的效用将在#年测试 小鼠模型 建议的商业应用：不可用

DESCRIPTION: (Adapted from the applicant's abstract) A number of strategies are under development by various groups for the creation of therapeutic tumor vaccines using gene transfer into autologous cells. However, gene transfer entails a number of technical problems that limit both the clinical utility and commercial viability of such vaccines. As an alternative, this project will generate a chimeric glycosylphosphatidylinositol-linked molecule that facilitates early events in the afferent limb of the immune response. The utility of this molecule in the creation of tumor vaccines will be tested in mouse models PROPOSED COMMERCIAL APPLICTION: NOT AVAILABLE