HISTOPATHOLOGIC STUDIES OF ASTHMA

哮喘的组织病理学研究

• 批准号: 6281956
• 负责人: Mark C Liu
• 金额: $ 5.69万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-10 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6281956
• 关键词: asthma; biopsy; bronchus; cellular immunity; clinical research; diagnostic respiratory lavage; eosinophil; histopathology; human subject; immunomodulators; inflammation; mast cell

Asthma is usually viewed as an airways disease where chronic inflammation plays an important role in pathogenesis. Some studies have used bronchoalveolar lavage (BAL) to assess airway inflammation by examining the fluids and cells recovered by this procedure. This approach has demonstrated levels of multiple inflammatory mediators such as histamine, tryptase, prostaglandins, leukotrienes, and kinins in BAL fluids from asthmatic subjects compared to normal subjects, as well as increased numbers of inflammatory cells, such as mast cells and eosinophils. Some of these abnormalities have been directly correlated with disease severity, decreased pulmonary function, and airway hyperactivity. The purpose of this study is to examine the relationship between inflammation assessed by examination of cells and mediators in BAL fluids and inflammation in airways assessed by bronchial biopsy.

哮喘通常被视为一种气道疾病， 在发病机制中发挥重要作用。一些研究使用 支气管肺泡灌洗（BAL），通过检查 通过这个过程回收的液体和细胞。这种方法有 显示了多种炎症介质如组胺的水平， 类胰蛋白酶、胰高血糖素、白三烯和激肽 哮喘患者与正常人相比， 炎性细胞的数量，如肥大细胞和嗜酸性粒细胞。一些 这些异常与疾病的严重程度直接相关， 肺功能下降和气道过度活跃 的目的 这项研究是为了检查炎症之间的关系， 支气管肺泡灌洗液中细胞和介质的检查以及支气管肺泡灌洗液中的炎症 通过支气管活检评估气道。