HISTOPATHOLOGIC STUDIES OF ALLERGIC INFLAMMATION OF AIRWAYS

气道过敏性炎症的组织病理学研究

• 批准号: 6281955
• 负责人: Mark C Liu
• 金额: $ 5.69万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-10 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6281955
• 关键词: allergens; asthma; cellular immunity; clinical research; corticosteroids; histopathology; hormone therapy; human subject; human therapy evaluation; inflammation; respiratory disorder chemotherapy; respiratory hypersensitivity

Asthma is a common airways disease in which inflammation plays a central role in pathogenesis. While the association of asthma is well established, the mechanisms by which allergic inflammation result in asthma have yet to be fully defined. This proosal will examine the biochemical and cellular mechanisms of inflammation in the model of segmental allergen challenge of the airways in allergic asthmatic subjects. Inflammation will be assessed by examination of cells and fluids obtained by bronchoalveolar lavage and of tissues obtained by bronchial biopsy. The kinetics of the allergic response of the airways will be examined from one hour to two weeks following challenge and the inter-relationship of inflammatory events including mediator release, cell recruitment, cytokine gene expression, appearance of cytokine products, and antibody production will be assessed. Recruitment, antigen specificity, and function of TH1/TH2 lymphocyte populations, will be a particular focus of the study. Finally, the effect of topical corticosteroids on airway function, inflammation, and the response to allergen challenge will be examined. These studies wil yield insights into the relatonship between allergic inflammation and asthma which can guide approaches to treatment.

哮喘是一种常见的呼吸道疾病，炎症在其中起重要作用。 在发病机制中的作用。虽然哮喘的关联已经确立， 过敏性炎症导致哮喘的机制尚不清楚 要有充分的定义。这份蜂胶将检测生化和细胞 节段性变应原激发大鼠模型的炎症机制 过敏性哮喘患者的呼吸道。将对炎症进行评估 通过对支气管肺泡灌洗所获得的细胞和液体的检查，以及 通过支气管镜活检获得的组织。过敏性疾病的动力学 呼吸道的反应将在一小时至两周内进行检查 接踵而至的挑战和炎症性事件的相互关系 包括介质释放，细胞募集，细胞因子基因表达， 将对细胞因子产物的外观和抗体产生进行评估。 TH1/TH2淋巴细胞的募集、抗原特异性和功能 人口，将是这项研究的特别重点。最后，效果 局部皮质类固醇对呼吸道功能、炎症和 将检查对变应原挑战的反应。这些研究将产生 对过敏性炎症与哮喘关系的洞察 它可以指导治疗方法。