INFLAMMATION IN AIRWAY DISEASE

气道疾病中的炎症

• 批准号: 6235041
• 负责人: Mark C Liu
• 金额: $ 13.17万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 1998-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6235041
• 关键词: Ambrosia; allergens; antiinflammatory agents; asthma; biopsy; bronchoscopy; clinical trials; cooperative study; corticosteroids; cytokine; delayed hypersensitivity; diagnostic respiratory lavage; flow cytometry; gene expression; helper T lymphocyte; histamine release; hormone therapy; human subject; human therapy evaluation; inflammation; leukocyte adhesion molecules; lymphocyte proliferation; respiratory airway pressure; spirometry; topical drug application

Asthma is a common airways disease in which inflammation plays a central role in pathogenesis. While the association of asthma and atopy is well established, the mechanisms by which allergic inflammation results in asthma have yet to be fully defined. This proposal will examine the biochemical and cellular mechanisms of inflammation in the model of segmental allergen challenge of the airways in allergic asthmatic subjects. Inflammation will be assessed by examination of cells and fluids obtained by bronchoalveolar lavage (BAL) and of tissues obtained by bronchial biopsy. The kinetics of the allergic response of the airways will be examined from l hour to 2 weeks following challenge, and the interrelationship of inflammatory events including mediator release, cell recruitment, cytokine gene expression, appearance of cytokine products, and antibody production will be assessed. The recruitment, antigen specificity, and function of THl/TH2 lymphocyte populations, will be a particular focus of study. Finally, the effect of topical corticosteroids on airway function, inflammation, and the response to allergen challenge will be examined. These studies will yield insights into the relationship between allergic inflammation and asthma which can guide approaches to treatment.

哮喘是一种常见的呼吸道疾病，炎症在其中起着中心作用。 在发病机制中的作用。虽然哮喘和特应性之间的联系很好， 建立，过敏性炎症导致的机制， 哮喘还没有被完全定义。本提案将审查 炎症的生物化学和细胞机制， 变应性哮喘患者气道节段性变应原激发试验 科目 炎症将通过检查细胞来评估， 通过支气管肺泡灌洗（BAL）获得的液体和通过 支气管活检 气道过敏反应的动力学 将在攻毒后1小时至2周进行检查， 炎症事件包括介质释放、细胞 募集，细胞因子基因表达，细胞因子产物的出现， 并评估抗体产生。 招募，抗原 TH 1/TH 2淋巴细胞群的特异性和功能，将是一个重要的研究领域。 特别是研究的重点。 最后，局部皮质类固醇的作用 对气道功能、炎症和过敏原激发反应的影响 将被审查。 这些研究将有助于深入了解 过敏性炎症和哮喘之间的联系， 治疗