INFLAMMATION IN AIRWAY DISEASE

哮喘是一种常见的呼吸道疾病，炎症在其中起重要作用。 在发病机制中的作用。虽然哮喘和特应性疾病之间的联系很好 已确定的过敏性炎症导致 哮喘的定义还没有完全明确。这项提案将审查 炎症模型中炎症的生化和细胞机制 过敏性哮喘患者呼吸道的节段性变应原激发 研究对象。炎症将通过检查细胞和 通过支气管肺泡灌洗(BAL)获得的液体和通过 支气管镜活检。呼吸道过敏反应的动力学研究 将在L挑战后的一小时至两周内进行检查，并 炎症事件的相互关系，包括介质释放、细胞 招募，细胞因子基因表达，细胞因子产物的出现， 并对抗体的产生进行评估。新征集的抗原 Th1/Th2淋巴细胞群的特异性和功能将是一个 特别是研究的重点。最后，局部使用皮质类固醇的效果 关于呼吸道功能、炎症和对变应原刺激的反应 将会被检查。这些研究将对两国关系产生深刻的影响。 过敏性炎症和哮喘之间的关系，这可以指导治疗 治疗。

Asthma is a common airways disease in which inflammation plays a central role in pathogenesis. While the association of asthma and atopy is well established, the mechanisms by which allergic inflammation results in asthma have yet to be fully defined. This proposal will examine the biochemical and cellular mechanisms of inflammation in the model of segmental allergen challenge of the airways in allergic asthmatic subjects. Inflammation will be assessed by examination of cells and fluids obtained by bronchoalveolar lavage (BAL) and of tissues obtained by bronchial biopsy. The kinetics of the allergic response of the airways will be examined from l hour to 2 weeks following challenge, and the interrelationship of inflammatory events including mediator release, cell recruitment, cytokine gene expression, appearance of cytokine products, and antibody production will be assessed. The recruitment, antigen specificity, and function of THl/TH2 lymphocyte populations, will be a particular focus of study. Finally, the effect of topical corticosteroids on airway function, inflammation, and the response to allergen challenge will be examined. These studies will yield insights into the relationship between allergic inflammation and asthma which can guide approaches to treatment.