INFLAMMATION IN AIRWAY DISEASE
INFLAMMATION IN AIRWAY DISEASE
批准号:
6099552
负责人:
Mark C Liu
金额:
$13.52万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-09-01 至 2000-08-31
关键词:
Ambrosia allergens antiinflammatory agents asthma biopsy bronchoscopy clinical trials cooperative study corticosteroids cytokine delayed hypersensitivity diagnostic respiratory lavage flow cytometry gene expression helper T lymphocyte histamine release hormone therapy human subject human therapy evaluation inflammation leukocyte adhesion molecules lymphocyte proliferation respiratory airway pressure spirometry topical drug application
中文摘要
哮喘是一种常见的呼吸道疾病,炎症在其中起着中心作用。
在发病机制中的作用。虽然哮喘和特应性之间的联系很好,
建立,过敏性炎症导致的机制,
哮喘还没有被完全定义。本提案将审查
炎症的生物化学和细胞机制,
变应性哮喘患者气道节段性变应原激发试验
科目 炎症将通过检查细胞来评估,
通过支气管肺泡灌洗(BAL)获得的液体和通过
支气管活检 气道过敏反应的动力学
将在攻毒后1小时至2周进行检查,
炎症事件包括介质释放、细胞
募集,细胞因子基因表达,细胞因子产物的出现,
并评估抗体产生。 招募,抗原
TH 1/TH 2淋巴细胞群的特异性和功能,将是一个重要的研究领域。
特别是研究的重点。 最后,局部皮质类固醇的作用
对气道功能、炎症和过敏原激发反应的影响
将被审查。 这些研究将有助于深入了解
过敏性炎症和哮喘之间的联系,
治疗
英文摘要
Asthma is a common airways disease in which inflammation plays a central
role in pathogenesis. While the association of asthma and atopy is well
established, the mechanisms by which allergic inflammation results in
asthma have yet to be fully defined. This proposal will examine the
biochemical and cellular mechanisms of inflammation in the model of
segmental allergen challenge of the airways in allergic asthmatic
subjects. Inflammation will be assessed by examination of cells and
fluids obtained by bronchoalveolar lavage (BAL) and of tissues obtained by
bronchial biopsy. The kinetics of the allergic response of the airways
will be examined from l hour to 2 weeks following challenge, and the
interrelationship of inflammatory events including mediator release, cell
recruitment, cytokine gene expression, appearance of cytokine products,
and antibody production will be assessed. The recruitment, antigen
specificity, and function of THl/TH2 lymphocyte populations, will be a
particular focus of study. Finally, the effect of topical corticosteroids
on airway function, inflammation, and the response to allergen challenge
will be examined. These studies will yield insights into the relationship
between allergic inflammation and asthma which can guide approaches to
treatment.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Dendritic cells and IgE in asthma
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批准号:7368057
-
项目类别:
-
资助金额:$38.14万
-
财政年份:2005
-
负责人:Mark C Liu
-
依托单位:
Dendritic cells and IgE in asthma
-
批准号:6969941
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项目类别:
-
资助金额:$34.6万
-
财政年份:2005
-
负责人:Mark C Liu
-
依托单位:
Dendritic cells and IgE in asthma
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批准号:7192524
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项目类别:
-
资助金额:$38.84万
-
财政年份:2005
-
负责人:Mark C Liu
-
依托单位:
Dendritic cells and IgE in asthma
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批准号:7576797
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项目类别:
-
资助金额:$38.14万
-
财政年份:2005
-
负责人:Mark C Liu
-
依托单位:
Dendritic cells and IgE in asthma
-
批准号:7066563
-
项目类别:
-
资助金额:$39.87万
-
财政年份:2005
-
负责人:Mark C Liu
-
依托单位:
HISTOPATHOLOGIC STUDIES OF ALLERGIC INFLAMMATION OF AIRWAYS
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批准号:6121415
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项目类别:
-
资助金额:$6.52万
-
财政年份:1998
-
负责人:Mark C Liu
-
依托单位:
HISTOPATHOLOGIC STUDIES OF ASTHMA
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批准号:6121416
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项目类别:
-
资助金额:$6.52万
-
财政年份:1998
-
负责人:Mark C Liu
-
依托单位:
HISTOPATHOLOGIC STUDIES OF ASTHMA
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批准号:6281956
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项目类别:
-
资助金额:$5.69万
-
财政年份:1998
-
负责人:Mark C Liu
-
依托单位:
HISTOPATHOLOGIC STUDIES OF ALLERGIC INFLAMMATION OF AIRWAYS
-
批准号:6281955
-
项目类别:
-
资助金额:$5.69万
-
财政年份:1998
-
负责人:Mark C Liu
-
依托单位:
INFLAMMATION IN AIRWAY DISEASE
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批准号:6235041
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项目类别:
-
资助金额:$13.17万
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财政年份:1997
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负责人:Mark C Liu
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依托单位:
HUMAN LUNG MACROPHAGE AND LMLAF EFFECTS ON LYMPHOCYTES
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批准号:3449355
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项目类别:
-
资助金额:$5.8万
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财政年份:1987
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负责人:Mark C Liu
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依托单位:
HUMAN LUNG MACROPHAGE AND LMLAF EFFECTS ON LYMPHOCYTES
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批准号:3449356
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项目类别:
-
资助金额:$6.09万
-
财政年份:1987
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负责人:Mark C Liu
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依托单位:
HUMAN LUNG MACROPHAGE AND LMLAF EFFECTS ON LYMPHOCYTES
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批准号:3449354
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项目类别:
-
资助金额:$5.34万
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财政年份:1987
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负责人:Mark C Liu
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依托单位:
HISTOPATHOLOGIC STUDIES OF ALLERGIC INFLAMMATION OF AIRWAYS
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批准号:6309419
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项目类别:
-
资助金额:$6.52万
-
财政年份:--
-
负责人:Mark C Liu
-
依托单位:
HISTOPATHOLOGIC STUDIES OF ALLERGIC INFLAMMATION OF THE AIRWAYS
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批准号:5224355
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:Mark C Liu
-
依托单位:--
HISTOPATHOLOGIC STUDIES OF ASTHMA
-
批准号:6309420
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项目类别:
-
资助金额:$6.52万
-
财政年份:--
-
负责人:Mark C Liu
-
依托单位:
INFLAMMATION IN AIRWAY DISEASE
-
批准号:5205496
-
项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:Mark C Liu
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依托单位:--
海外基金