BONE MINERAL DENSITY--INFLUENCE OF AGE AND RACE

骨矿物质密度——年龄和种族的影响

• 批准号: 6281936
• 负责人: JAY Robert SHAPIRO
• 金额: $ 5.69万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-10 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6281936
• 关键词: African American; Asian Americans; Native Americans; age difference; aging; bone density; bone metabolism; caucasian American; clinical research; diet; female; gender difference; human subject; longitudinal human study; male; pathologic bone resorption; photon absorptiometry; physiologic bone resorption; postmenopause; racial /ethnic difference; serum

The purpose of this study is to determine differences in bone loss between women, in postmenopausal age range and ethnically similar men (ages 55-75 years) and to correlate these differences with blood and urine measurements of bone metabolism. Bone mass decreases with increasing age in both men and women. In addition to differences based on gender and age, there are also differences in bone loss based on race. It has been know for some time that bone loss in black man and women is slower than that in white men and women. Although technology (DEXA scan) aimed at determining bone loss prior to the occurrence of fracture has advanced lately, bone density scans or the measurement of serum indices of bone turnover have not been obtained in aged women. Also, correlation of such with race has not been accomplished. In effect, the absence of this information leaves a substantial portion of the aging population at risk for fracture without the benefit of preventive measures such as hormone replacement in the postmenopausal years, and/or dietary calcium supplementation. We seek to correlate bone mineral density (BMD) at two sites with serum and urine parameters of skeletal turnover over a period of 24 months in a population of aging black and white men and postmenopausal black and white women.

本研究的目的是确定 绝经后年龄范围内的女性和种族相似的男性（年龄55-75 并将这些差异与血液和尿液相关联 骨代谢的测量。 男性和女性的骨质都随着年龄的增长而减少。此外 除了性别和年龄的差异外， 基于种族的损失。一段时间以来，人们已经知道， 男性和女性比白色男性和女性慢。虽然 技术（DEXA扫描），旨在确定骨丢失之前， 骨折的发生最近已经进展，骨密度扫描或 骨转换的血清指标的测量尚未获得， 老年妇女。此外，这种与种族的相关性尚未完成。 事实上，缺乏这一信息， 老年人有骨折的风险， 预防措施，如绝经后的激素替代 年，和/或膳食钙补充剂。 我们试图将两个部位的骨密度（BMD）与血清 在24个月的时间内， 老年黑人和白色男性以及绝经后的黑人和 白色女人。