BONE MINERAL DENSITY--INFLUENCE OF AGE AND RACE

骨矿物质密度——年龄和种族的影响

• 批准号: 6121396
• 负责人: JAY Robert SHAPIRO
• 金额: $ 6.52万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6121396
• 关键词: African American; Asian Americans; Native Americans; age difference; aging; bone density; bone metabolism; caucasian American; clinical research; diet; female; gender difference; human subject; longitudinal human study; male; pathologic bone resorption; photon absorptiometry; physiologic bone resorption; postmenopause; racial /ethnic difference; serum

Bone mass decreases with increasing age in both men and women. Factors that influence the rate of bone loss include age and gender, as well as race. Bone loss in African American men and women is slower than in Caucasian men and women. Bone density scans, which have become the "gold standard" for measuring bone loss, have not adequately addressed gender- based differences in osteopenia in an aging population. Furthermore, the comparison of African American bone loss rates with those of Caucasians has not received adequate study. The goal of this protocol is to correlate bone mineral density (BMD) at two anatomical sites with serum and urine markers of skeletal turnover over a period of 24 months in a population of aging African American and Caucasian men and postmenopausal women. During this reporting period, the final five patients were studied. The results of the entire study indicate that while DEXA scans may be the gold standard for staging bone loss, the urinary marker deoxypyridinoline appears to be the most informative biomarker for dynamic bone loss. The serum markers osteocalcin and procollagen type I carboxyl terminal peptide exhibited a lack of correlation with ethnicity and gender. Because of limited enrollment in this study (70 total), the results lack the power to define statistically meaningful differences between the multiple subgroups stratified by age, gender and ethnicity. The results do confirm previous observations of higher bone mass and reduced rate of bone loss in the African American study population.

男性和女性的骨量随着年龄的增长而减少。影响骨质流失率的因素包括年龄、性别以及种族。非裔美国人的骨质流失比白人男性和女性慢。骨密度扫描，已成为测量的“金标准” 骨丢失，还没有充分解决老龄人口中骨质减少的性别差异。此外，非洲裔美国人与高加索人骨丢失率的比较尚未得到充分的研究。本方案的目的是在24个月的时间内，在一个老龄化的非洲裔美国人和白人男性和绝经后女性人群中，将两个解剖部位的骨矿物质密度（BMD）与骨骼转换的血清和尿液标志物相关联。在本报告期间，对最后5例患者进行了研究。整个研究的结果表明，尽管DEXA扫描可能是骨丢失分期的金标准，但尿标记物脱氧吡啶啉似乎是最重要的。 动态骨丢失的信息性生物标志物。血清标志物骨钙素和I型前胶原羧基末端肽表现出缺乏相关性与种族和性别。由于本研究的入组人数有限（共70人），因此结果无法定义按年龄、性别和种族分层的多个亚组之间的统计学显著差异。结果证实了先前在非裔美国人研究人群中观察到的较高骨量和骨丢失率降低。