EVALUATION OF GH EFFECTS ON REE AND BODY COMPOSITION OF CHILDREN WITH PWS

评估 GH 对 PWS 儿童的 REE 和身体成分的影响

• 批准号: 6282089
• 负责人: DAVID B ALLEN
• 金额: $ 2.43万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6282089
• 关键词: Prader Willi syndrome; basal metabolism; bioenergetics; body composition; bone density; cardiovascular disorder; child (0-11); child physical development; clinical research; clinical trial phase I; disease /disorder proneness /risk; human subject; human therapy evaluation; muscle strength; nutrient intake activity; nutrition related tag; respiratory function; somatotropin

We seek support to investigate the anabolic effects of growth hormone (GH) on body composition in children with a genetic form of obesity, Prader-Willi Syndrome (PWS). We have begun to study the metabolic effects of GH on body composition including linear growth rate, bone density, nutrient intake, and cardiovascular risk factors including resting energy expenditure, lean body mass and percent body fat, muscle strength and agility, pulmonary function, as well as carbohydrate and lipid metabolism. This patient population provides a model with known risk factors for genetic obesity, and metabolic consequences of growth hormone deficiency. Recent investigations have shown anabolic effects of GH improving body composition, while decreasing obesity and other cardiovascular risk factors. We have been awarded peer reviewed funding for a comprehensive controlled study, which provides a unique opportunity to engage in multi-disciplinary clinical research. However, since the time of this clinical grant award, we have added an additional facet to the study: the measurement of resting energy expenditure (REE). Sufficient funds have been obtained to accomplish the majority of study objectives, but not for REE measurements. The measurement of REE utilizing respiratory quotient measurements contributes substantial scientific value to the study protocol, and will be directly applicable to future investigations of metabolic effects of GH and other anabolic hormones on body composition. This assessment will provide important information about factors leading to abnormal body composition in PWS, while further preparing the fellow to conduct important future investigations of the metabolic effects of GH on body composition and obesity.

我们寻求支持，以调查生长激素的合成代谢作用 (GH)对遗传性肥胖儿童的身体组成的影响， Prader-Willi综合征（PWS）。 我们已经开始研究 生长激素对身体组成的影响，包括线性生长率，骨 密度、营养摄入量和心血管风险因素，包括 静息能量消耗、瘦体重和体脂百分比、肌肉 力量和敏捷性，肺功能，以及碳水化合物， 脂质代谢 该患者人群提供了一个已知的模型， 遗传性肥胖的风险因素和生长的代谢后果 激素缺乏症 最近的研究表明， 生长激素改善身体成分，同时减少肥胖和其他 心血管危险因素。 我们已经获得了同行评审的资金， 对照研究，这提供了一个独特的机会， 多学科临床研究。 然而，自从这件事发生以来， 临床奖，我们增加了一个额外的方面的研究： 静息能量消耗（REE）的测量。 足够的资金 已经获得了实现大多数研究目标，但 不用于REE测量。 呼吸道微量元素测定 商数的测量对科学研究具有重要的科学价值， 研究方案，并将直接适用于未来的研究 生长激素和其他合成代谢激素对身体的代谢作用 混合物. 该评估将提供有关以下方面的重要信息： 导致PWS身体成分异常的因素，而进一步 准备研究员进行重要的未来调查的 GH对身体组成和肥胖的代谢作用。