Childhood Diabetes Clinical & Molecular Research Training Program

儿童糖尿病临床

• 批准号: 8664579
• 负责人: DAVID B ALLEN
• 金额: $ 12.76万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8664579
• 关键词: Childhood; Clinical; Diabetes Mellitus; Molecular; Research Training; Training Programs

DESCRIPTION (provided by applicant): The goal of the Childhood Diabetes Clinical & Molecular Research Training Program (CDCMRT) is to train MD pediatric endocrinology fellows and PhD fellows for academic research careers in type 2 diabetes, insulin resistance, obesity and fitness in children. Insulin resistance, usually associated with obesity and increasingly leading to overt diabetes, has become a major health problem in children. Research fellows in this program have the opportunity to begin a career in molecular and cellular research in internationally recognized laboratories engaged in biochemical and molecular genetic studies of pancreatic islet biology, insulin sensitivity, or whole body pathophysiology studying human metabolism, energy expenditure, adiposity, fitness, androgen excess and the metabolic syndrome in ethnically diverse children and adolescents. Objectives include 1) establishment of a high quality and productive research project, 2) development of a progressive record of publication in respected research journals, 3) application for and procurement of extramural grant funding during fellowship, and 4) pursuit of academic careers in childhood diabetes, insulin resistance and obesity research by a minimum of 50% of the graduates of this program. To achieve these objectives, a curriculum has been developed in collaboration with the NIH-funded University of Wisconsin Institute for Clinical and Translational Research Program (ICTR) to provide training in diabetes and insulin resistance, research techniques, statistics and study design, medical ethics, scientific writing and presentation skills, and preparation of grant applications. CDCMRT research opportunities involve clinical, translational, and basic science activities that have been both independently and collaboratively successful and are directed towards the study of diabetes and insulin resistance diseases. The continually rising burden of diabetes and other obesity-related metabolic disorders, the strong record of accomplishment of our first group of T32-supported fellows and recognition of a national shortage of basic science researchers and pediatric endocrinologists with childhood obesity and type 2 diabetes training prompt us to seek continued funding for the CDCMRT program. The University of Wisconsin Center for the Study of Diversity in Health Care will assist the CDCMRT in recruiting under-represented minority trainee candidates. Given the opportunity, the CDCMRT program will continue to provide trainees with a comprehensive mentored research training experience that will prepare them for innovative, productive research careers in childhood diabetes, insulin resistance and obesity.

描述(由申请者提供)：儿童糖尿病临床和分子研究培训计划(CDCMRT)的目标是为儿童的2型糖尿病、胰岛素抵抗、肥胖和健康方面的学术研究生涯培训MD儿科内分泌学研究员和博士研究员。胰岛素抵抗通常与肥胖有关，并日益导致明显的糖尿病，已成为儿童的主要健康问题。该项目的研究员有机会在国际公认的实验室开始分子和细胞研究生涯，这些实验室从事胰岛生物学、胰岛素敏感性或全身病理生理学的生化和分子遗传学研究，研究人类代谢、能量消耗、肥胖、健身、雄激素过剩和不同种族儿童和青少年的代谢综合征。目标包括1)建立一个高质量和富有成效的研究项目，2)在受人尊敬的研究期刊上发展一个渐进的发表记录，3)在奖学金期间申请和获得外部资助，以及4)至少50%的该项目的毕业生追求在儿童糖尿病、胰岛素抵抗和肥胖研究方面的学术生涯。为了实现这些目标，与美国国立卫生研究院资助的威斯康星大学临床和翻译研究计划(ICTR)合作开发了一门课程，提供糖尿病和胰岛素抵抗、研究技术、统计学和研究设计、医学伦理、科学写作和演示技能以及拨款申请准备方面的培训。CDCMRT的研究机会包括临床、翻译和基础科学活动，这些活动独立和合作都取得了成功，并针对糖尿病和胰岛素抵抗疾病的研究。糖尿病和其他肥胖相关代谢紊乱的负担持续增加，我们第一批T32支持的研究员取得了良好的成就，全国范围内缺乏患有儿童肥胖症和2型糖尿病的基础科学研究人员和儿科内分泌学家，这促使我们为CDCMRT计划寻求持续的资金。威斯康星大学卫生保健多样性研究中心将协助CDCMRT招募代表性不足的少数族裔受训候选人。如果有机会，CDCMRT计划将继续为学员提供全面的导师式研究培训体验，为他们在儿童糖尿病、胰岛素抵抗和肥胖症方面的创新、富有成效的研究生涯做好准备。