Childhood Diabetes Clinical & Molecular Research Training Program

描述（由申请人提供）：儿童糖尿病临床和分子研究培训计划（CDCMRT）的目标是培训医学博士儿科内分泌学研究员和博士研究员，从事2型糖尿病，胰岛素抵抗，肥胖和儿童健康的学术研究事业。胰岛素抵抗通常与肥胖有关，并日益导致明显的糖尿病，已成为儿童的主要健康问题。该计划的研究员有机会开始在国际公认的实验室从事分子和细胞研究的职业生涯，这些实验室从事胰岛生物学，胰岛素敏感性或全身病理生理学的生物化学和分子遗传学研究，研究人类代谢，能量消耗，肥胖，健身，雄激素过多和不同种族儿童和青少年的代谢综合征。目标包括：1）建立高质量和富有成效的研究项目，2）在受人尊敬的研究期刊上开发出版物的进步记录，3）申请和采购奖学金期间的校外资助资金，以及4）追求儿童糖尿病，胰岛素抵抗和肥胖研究的学术事业，该计划的毕业生至少有50%。为了实现这些目标，与美国国立卫生研究院资助的威斯康星州大学临床和转化研究计划研究所（ICTR）合作开发了一个课程，提供糖尿病和胰岛素抵抗、研究技术、统计和研究设计、医学伦理、科学写作和演讲技巧以及准备拨款申请方面的培训。CDCMRT研究机会涉及临床，转化和基础科学活动，这些活动既独立又合作成功，并针对糖尿病和胰岛素抵抗疾病的研究。糖尿病和其他肥胖相关代谢紊乱的负担不断上升，我们的第一组T32支持的研究员取得的成就以及对全国缺乏基础科学研究人员和儿童肥胖和2型糖尿病培训的儿科内分泌学家的认识促使我们继续为CDCMRT计划寻求资金。威斯康星州大学医疗保健多样性研究中心将协助CDCMRT招募代表性不足的少数族裔实习生候选人。有了这个机会，CDCMRT计划将继续为学员提供全面的指导研究培训经验，为他们在儿童糖尿病，胰岛素抵抗和肥胖方面的创新，富有成效的研究事业做好准备。

DESCRIPTION (provided by applicant): The goal of the Childhood Diabetes Clinical & Molecular Research Training Program (CDCMRT) is to train MD pediatric endocrinology fellows and PhD fellows for academic research careers in type 2 diabetes, insulin resistance, obesity and fitness in children. Insulin resistance, usually associated with obesity and increasingly leading to overt diabetes, has become a major health problem in children. Research fellows in this program have the opportunity to begin a career in molecular and cellular research in internationally recognized laboratories engaged in biochemical and molecular genetic studies of pancreatic islet biology, insulin sensitivity, or whole body pathophysiology studying human metabolism, energy expenditure, adiposity, fitness, androgen excess and the metabolic syndrome in ethnically diverse children and adolescents. Objectives include 1) establishment of a high quality and productive research project, 2) development of a progressive record of publication in respected research journals, 3) application for and procurement of extramural grant funding during fellowship, and 4) pursuit of academic careers in childhood diabetes, insulin resistance and obesity research by a minimum of 50% of the graduates of this program. To achieve these objectives, a curriculum has been developed in collaboration with the NIH-funded University of Wisconsin Institute for Clinical and Translational Research Program (ICTR) to provide training in diabetes and insulin resistance, research techniques, statistics and study design, medical ethics, scientific writing and presentation skills, and preparation of grant applications. CDCMRT research opportunities involve clinical, translational, and basic science activities that have been both independently and collaboratively successful and are directed towards the study of diabetes and insulin resistance diseases. The continually rising burden of diabetes and other obesity-related metabolic disorders, the strong record of accomplishment of our first group of T32-supported fellows and recognition of a national shortage of basic science researchers and pediatric endocrinologists with childhood obesity and type 2 diabetes training prompt us to seek continued funding for the CDCMRT program. The University of Wisconsin Center for the Study of Diversity in Health Care will assist the CDCMRT in recruiting under-represented minority trainee candidates. Given the opportunity, the CDCMRT program will continue to provide trainees with a comprehensive mentored research training experience that will prepare them for innovative, productive research careers in childhood diabetes, insulin resistance and obesity.