EVALUATION OF GH EFFECTS ON REE AND BODY COMPOSITION OF CHILDREN WITH PWS

评估 GH 对 PWS 儿童的 REE 和身体成分的影响

• 批准号: 6121717
• 负责人: DAVID B ALLEN
• 金额: $ 3.35万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6121717
• 关键词: Prader Willi syndrome; basal metabolism; bioenergetics; body composition; bone density; cardiovascular disorder; child (0-11); child physical development; clinical research; clinical trial phase I; disease /disorder proneness /risk; human subject; human therapy evaluation; muscle strength; nutrient intake activity; nutrition related tag; respiratory function; somatotropin

We seek support to investigate the anabolic effects of growth hormone (GH) on body composition in children with a genetic form of obesity, Prader-Willi Syndrome (PWS). We have begun to study the metabolic effects of GH on body composition including linear growth rate, bone density, nutrient intake, and cardiovascular risk factors including resting energy expenditure, lean body mass and percent body fat, muscle strength and agility, pulmonary function, as well as carbohydrate and lipid metabolism. This patient population provides a model with known risk factors for genetic obesity, and metabolic consequences of growth hormone deficiency. Recent investigations have shown anabolic effects of GH improving body composition, while decreasing obesity and other cardiovascular risk factors. We have been awarded peer reviewed funding for a comprehensive controlled study, which provides a unique opportunity to engage in multi-disciplinary clinical research. However, since the time of this clinical grant award, we have added an additional facet to the study: the measurement of resting energy expenditure (REE). Sufficient funds have been obtained to accomplish the majority of study objectives, but not for REE measurements. The measurement of REE utilizing respiratory quotient measurements contributes substantial scientific value to the study protocol, and will be directly applicable to future investigations of metabolic effects of GH and other anabolic hormones on body composition. This assessment will provide important information about factors leading to abnormal body composition in PWS, while further preparing the fellow to conduct important future investigations of the metabolic effects of GH on body composition and obesity.

我们寻求支持，以调查生长激素（GH）对儿童的身体组成的合成代谢的影响与遗传形式的肥胖，普拉德-威利综合征（PWS）。 我们已经开始研究生长激素对身体组成的代谢影响，包括线性生长率，骨密度，营养摄入，以及心血管风险因素，包括静息能量消耗，瘦体重和体脂百分比，肌肉力量和敏捷性，肺功能，以及碳水化合物和脂质代谢。 该患者人群提供了一个具有已知遗传性肥胖风险因素和生长激素缺乏症代谢后果的模型。 最近的研究表明，生长激素的合成代谢作用改善身体组成，同时减少肥胖和其他心血管危险因素。我们已经获得了同行评审的资金，用于一项全面的对照研究，这为从事多学科临床研究提供了一个独特的机会。 然而，自从这项临床研究基金颁发以来，我们在这项研究中增加了一个额外的方面：静息能量消耗（REE）的测量。 已经获得了足够的资金来完成大部分的研究目标，但没有REE测量。 利用呼吸商测量REE的测量为研究方案提供了大量的科学价值，并将直接适用于GH和其他合成代谢激素对身体组成的代谢影响的未来研究。 这项评估将提供有关导致PWS身体组成异常的因素的重要信息，同时进一步准备研究员进行GH对身体组成和肥胖的代谢影响的重要未来调查。