AMYGDALA AND SLEEP

描述：(改编自《调查者摘要》) 与压力相关的睡眠障碍，特别是失眠，在 普通人口。很少有好的动物模型可以用来研究 失眠或睡眠异常的潜在机制 精神障碍。内德·卡林博士一直在研究杏仁核的作用。 在恒河猴情绪加工中，一个与人类相关的模型 情绪和精神变态。与卡林博士合作，校长 研究人员获得了患有杏仁核的恒河猴的初步数据 提示杏仁核介导压力对睡眠和睡眠的影响的损害 在组织REM/NREM睡眠周期中可能也很重要。 在这份修订的提案中，首席调查员计划研究恒河猴 全部、双侧杏仁核病变和双侧杏仁核病变的猴子 杏仁核杏仁核的中央核，杏仁核的主要输出部位。 利用遥测技术，她将比较正常、不受约束的睡眠模式 并对各种压力源做出反应。这些研究将 确定杏仁核在正常睡眠组织中的作用以及在 对情绪和身体压力的反应。从这些数据中获得的结果 研究应该增加我们对睡眠潜在机制的理解 精神障碍和失眠的异常。

DESCRIPTION: (Adapted from the Investigator's Abstract) Stress-related sleep disorders, notably insomnia, are widely prevalent in the general population. There are few good animal models in which to study the mechanisms underlying insomnia or the sleep abnormalities associated with psychiatric disorders. Dr. Ned Kalin has been studying the role of the amygdala in emotional processing in the rhesus monkey, a relevant model for human emotion and psychopathology. In collaboration with Dr. Kalin, the Principal Investigator has obtained preliminary data from rhesus monkeys with amygdala lesions which suggest that the amygdala mediates stress effects on sleep and may be important in organizing REM/NREM sleep cycles as well. In this revised proposal, the Principal Investigator plans to study rhesus monkeys with total, bilateral lesions of the amygdala, and bilateral lesions of the central nucleus of the amygdala, the major output site from the amygdala. Using telemetry, she will compare sleep patterns under normal, unrestrained conditions and in response to a variety of stressors. These studies will establish the role of the amygdala in normal sleep organization as well as in response to emotional and physical stressors. Results obtained from these studies should increase our understanding of the mechanisms underlying sleep abnormalities in psychiatric disorders and insomnia.