AUTOCLAVABLE SENSOR FOR IN SITU BIOREACTOR MONITORING

用于原位生物反应器监测的可高温高压灭菌传感器

• 批准号: 6013453
• 负责人: JAMES A KANE
• 金额: $ 9.99万
• 依托单位: POLESTAR TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6013453
• 关键词: antiseptic sterilization; biomedical equipment development; bioreactors; boron; chemical stability; chemical synthesis; colloids; glucose; heat; monitoring device; polymers

This Small Business Innovation Research Phase I project will demonstrate the feasibility of a unique glucose-sensing hydrogel membrane to be incorporated, in a phase II effort, into an innovative sensor for continuous in situ glucose monitoring in bioprocessing reactors and improved performance and cost effectiveness being realized as aq result of reduced analysis time, complexity, and risk of microbial contamination as compared to the current on-line monitoring technologies. PROPOSED COMMERCIAL APPLICATIONS: Today, success in the applications of modern biotechnological techniques is evidenced by the variety of products ranging from specialty chemicals, polymers, and food to therapeutic drugs, produced by using recombinant DNA methodologies in various cell cultured systems. There is a constant need to develop and implement a new sensing system to effectively control and optimize these biological processes. The potential market for the use of a reliable stable glucose sensor for monitoring in bioreactors and/or fermenters exists. Through our initial contact with several pharmaceutical/biotechnology companies, the response is overwhelmingly positive. By forming a strategic alliance with these companies and academic institutions to test and evaluate the sensing system, the sensor will be quickly adapted for different industrial bioreactor settings.

这个小企业创新研究第一阶段项目将证明一种独特的葡萄糖传感水凝胶膜的可行性，在第二阶段的努力中，将其纳入一种创新的传感器中，用于生物加工反应器中的连续原位葡萄糖监测，并提高性能和成本效益，因为减少了分析时间，复杂性，和微生物污染的风险。拟议的商业应用：今天，现代生物技术应用的成功通过在各种细胞培养系统中使用重组DNA方法生产的从特种化学品、聚合物和食品到治疗药物的各种产品来证明。一直需要开发和实施新的传感系统来有效地控制和优化这些生物过程。在生物反应器和/或发酵罐中使用可靠稳定的葡萄糖传感器进行监测的潜在市场存在。通过我们与几家制药/生物技术公司的初步接触，反应非常积极。通过与这些公司和学术机构结成战略联盟来测试和评估传感系统，传感器将快速适应不同的工业生物反应器设置。