PRODUCTION OF Y90 MICROSPHERES FOR RADIATION THERAPY

低成本制备单分散计时生物可吸收微球 含有Y-90(Y-90)将对辐射产生积极影响 在美国和世界范围内的治疗。随着更多的强调 医疗行业的半衰期短、能量高、贝塔辐射 同位素(如7-90)，以减少放射治疗的主要副作用，Y- 90已经成为人们选择的同位素。随着更多的治疗用途被 发现了短半衰期的同位素，这是必要的 将涉及同位素的处理时间保持在绝对最短的水平。一个完整的 自动化生产过程将确保新鲜的(不会腐烂的)供应 微球，将最大限度地减少或完全消除人员接触 辐射或放射性材料，并将利用源同位素 例如锶-90(锶-90)在以下方面最有效和自然地 材料和放射性同位素寿命。这就是这项提议的目标 计划整合来自全国各地的示范技术和知识 使用XL科技的Timed-Resbable的实验室和私营行业 微球技术。通过工艺创新，持续降低成本 将实现Y-90微球的批量生产。 建议的商业应用： 含有Y-90、P-30等同位素的微球是直接用于 瘤内注射治疗肝癌、胰腺癌等 类风湿性关节炎的放射滑膜切除术。

Low-cost production of monodispersed timed-bioresorbable microspheres containing yttrium-90 (Y-90) will have a positive impact on radiation therapy in the United States and world wide. As more emphasis is given by the medical profession to short half-life, high energy, beta emitting isotopes (such as 7-90) to minimize major side effects of radiotherapy, Y- 90 has become the isotope of choice. As more therapeutic uses are being discovered for the short half-life isotope, it is necessary that the processing time involving isotopes be kept to an absolute minimum. A fully automated production process will ensure a fresh (non-decayed) supply of microsphere, will minimize or completely eliminate personnel exposure to radiation or radioactive materials, and will utilize the source isotopes such as strontium-90 (Sr-90) most efficiently and naturally in terms of material and radioisotope life. It is the objective of this proposed program to integrate demonstrated technologies and knowledge from national laboratories and private industries with XL Sci-Tech's timed-resorbable microsphere technology. Through process innovation, continuous low cost volume production of Y-90 microspheres will be achieved. Proposed commercial application: Microspheres containing isotopes such as Y-90, P-30 are ideal for direct intratumorial injection in treatment of cancers of liver, pancreas etc., and radiation synovectomy of rheumatoid arthritis.