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Nano Radioisotope Sources For Targeted Radiation Therapy

用于靶向放射治疗的纳米放射性同位素源

基本信息

批准号：
7540344
负责人：
YONGREN Benjamin PENG
金额：
$ 14.04万
依托单位：
XL SCI-TECH, INC.
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-01 至 2009-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7540344
关键词：
90Y Agreement Antibodies Binding Binding Sites Biotin Body Fluids Bone Tissue Cadmium Chemical Structure Chemicals Chemistry Citric Acid Class Collaborations Complement Complication Consult Containment Coupling Cyclotrons Department of Energy Depth Development Diagnostic Diagnostic Imaging Dose Effectiveness Ensure Enzymes Evaluation Extravasation Future Half-Life Hand High temperature of physical object Hour Immobilization In Vitro Indium Indium-111 Individual Injection of therapeutic agent Isotopes Label Link Measurement Measures Metals Mono-S Nature Nuclear Reactors Nuclear Weapon Numbers Object Attachment Oxidation-Reduction Parents Penetration Peptides Phase Phosphate Buffer Physical condensation Play Positron-Emission Tomography Process Production Proteins Protons Public Health Purpose Radiation therapy Radio Radioactive Radioactivity Radioisotopes Range Reaction Research Research Activity Research Personnel Rhenium 186 Role Silicon Dioxide Simulate Site Solutions Source Specialist Standards of Weights and Measures Strontium-90 Surface System Targeted Research Therapeutic Tissues Toxic effect Tracer Work Yttrium base biomaterial compatibility bone cost experience fiberglass hydroxyl group improved in vivo irradiation man metal oxide nano nanometer nanoscale nanosized particle research and development size success targeted delivery tumor

项目摘要

DESCRIPTION (provided by applicant): Radioisotopes used in targeted therapy are often labeled to targeting biomolecules. Different radioisotope and biomolecule usually require different linkage to bind the radioisotope to the targeting biomolecule. This proposed research is to create modular nano radioisotope sources for improving tumor targeting. Using fusion at the nano-scale, a class of new and low cost radioisotope sources can be created with the most desirable energy spectrum possible and can be modularized and functionalized to revolutionize targeted delivery. Phase I of the proposed research will focus on the creation and functionalization of the nano-fused radioisotope sources. These nano radioisotopes are, potentially, ideal to be functionalized as a modular labeling block especially useful for targeted therapy. In vitro characterization of modularized and functionalized nano radioisotope sources will include radioactivity containment measurements in simulated body fluid. The labeling of such nano-fused radioisotope sources to selected biomolecules will be the focus of the Phase II research. PUBLIC HEALTH RELEVANCE: Tumor targeting is similar to a smart bomb aiming and destroying its target. The complication is to discover a working linkage to couple between a selected radioisotope (the "bomb") and a chosen targeting biomolecule. This project takes the first step in creating a "plug-and-play" tumor targeting system by modularizing radioisotope sources using fusion at the nano-scale such that linkages to radioisotopes are simplified to ONE reliable and standard linkage.

描述（由申请人提供）：靶向治疗中使用的放射性同位素通常被标记为靶向生物分子。不同的放射性同位素和生物分子通常需要不同的连接来将放射性同位素与靶向生物分子结合。这项拟议的研究旨在创建模块化纳米放射性同位素源，以改善肿瘤靶向性。利用纳米级聚变，可以创造出一类具有最理想能谱的新型低成本放射性同位素源，并且可以模块化和功能化以彻底改变靶向输送。拟议研究的第一阶段将重点关注纳米融合放射性同位素源的创建和功能化。这些纳米放射性同位素可能非常适合用作模块化标记块，特别适用于靶向治疗。模块化和功能化纳米放射性同位素源的体外表征将包括模拟体液中的放射性遏制测量。将这种纳米融合放射性同位素源标记到选定的生物分子将是第二阶段研究的重点。公共卫生相关性：肿瘤靶向类似于瞄准并摧毁目标的智能炸弹。复杂之处在于发现选定的放射性同位素（“炸弹”）和选定的靶向生物分子之间的有效联系。该项目迈出了创建“即插即用”肿瘤靶向系统的第一步，通过使用纳米级融合对放射性同位素源进行模块化，从而将放射性同位素的连接简化为一个可靠且标准的连接。