Nano Radioisotope Sources For Targeted Radiation Therapy

描述（由申请人提供）：用于靶向治疗的放射性同位素通常被标记为靶向生物分子。不同的放射性同位素和生物分子通常需要不同的键将放射性同位素与靶向生物分子结合。本研究旨在创建模块化纳米放射性同位素源，以提高肿瘤靶向性。利用纳米尺度的核聚变，可以创造出一类新的低成本放射性同位素源，具有最理想的能谱，并且可以模块化和功能化，从而彻底改变靶向递送。拟议研究的第一阶段将侧重于纳米聚变放射性同位素源的创建和功能化。这些纳米放射性同位素可能是理想的功能化模块标记块，特别适用于靶向治疗。模块化和功能化纳米放射性同位素源的体外表征将包括模拟体液中的放射性遏制测量。将这种纳米聚变放射性同位素源标记为选定的生物分子将是第二阶段研究的重点。与公共卫生相关：肿瘤定位类似于智能炸弹瞄准并摧毁其目标。复杂之处在于，要在选定的放射性同位素（“炸弹”）和选定的目标生物分子之间找到一种有效的联系。该项目迈出了创建“即插即用”肿瘤靶向系统的第一步，通过纳米级核聚变将放射性同位素源模块化，从而将放射性同位素的连接简化为一个可靠的标准连接。

DESCRIPTION (provided by applicant): Radioisotopes used in targeted therapy are often labeled to targeting biomolecules. Different radioisotope and biomolecule usually require different linkage to bind the radioisotope to the targeting biomolecule. This proposed research is to create modular nano radioisotope sources for improving tumor targeting. Using fusion at the nano-scale, a class of new and low cost radioisotope sources can be created with the most desirable energy spectrum possible and can be modularized and functionalized to revolutionize targeted delivery. Phase I of the proposed research will focus on the creation and functionalization of the nano-fused radioisotope sources. These nano radioisotopes are, potentially, ideal to be functionalized as a modular labeling block especially useful for targeted therapy. In vitro characterization of modularized and functionalized nano radioisotope sources will include radioactivity containment measurements in simulated body fluid. The labeling of such nano-fused radioisotope sources to selected biomolecules will be the focus of the Phase II research. PUBLIC HEALTH RELEVANCE: Tumor targeting is similar to a smart bomb aiming and destroying its target. The complication is to discover a working linkage to couple between a selected radioisotope (the "bomb") and a chosen targeting biomolecule. This project takes the first step in creating a "plug-and-play" tumor targeting system by modularizing radioisotope sources using fusion at the nano-scale such that linkages to radioisotopes are simplified to ONE reliable and standard linkage.