TIMED BIORESORBABLE Y 90 MICROSPHERES FOR RADIOTHERAPY

描述：放射性物质从注射过程中泄漏 网站降低了治疗效果，导致对正常的不良损害 组织，并增加副作用(皮炎、神经炎)和 继发性肿瘤(白血病和骨肉瘤)。不溶玻璃或 陶瓷微球可能含有对注射部位的放射性 抑制渗漏，但也可能在以后引发炎症、恶化 组织损伤和纤维化，或对愈合造成物理损害/愈合 关节。这些障碍可能会通过一种新的、适时的- 可生物吸收的磷酸钙微球。这些微球可以 被要求保持结构完整性30天(11物理半- Y-90的生命，即衰败到可以忽略不计的活动)在它们开始之前 以预定的速度溶解，在病人体内不留任何东西 造成刺激、堵塞或身体损害。这样做的目的是 项目是用预制棒制备和测试含Y-90的微球 程序化的生物再吸收。玻璃成分范围和Y-90溶解度 在眼镜中将被确立。人血清白蛋白体外性质的研究 可生物吸收的Y-90磷酸钙玻璃微球将 其特点是可以在实验室中进行后续测试 动物。Y-90微球的应用包括直接瘤内治疗 注射(近距离放射治疗)治疗肝癌 胰腺、脑等，类风湿放射滑膜切除术 关节炎。

DESCRIPTION: Leakage of radioactive material away from the injection site reduces therapeutic efficacy, induces undesirable damage to normal tissues, and increases the risk of side effects (dermitis, neuritis) and secondary neoplasia (leukemia and osteosarcoma). Insoluble glass or ceramic microspheres may contain radioactivity to the injection site and inhibit leakage, but may also later induce inflammation, deterioration of tissues, and fibrosis, or cause physical damage to healing/healed joints. These obstacles may be overcome with a new, timed- bioresorbable calcium phosphate microspheres. These microspheres can be made to maintain structural integrity for 30 days (11 physical half- lives for Y-90, i.e., decayed to negligible activity) before they begin to dissolve at a predetermined rate, leaving nothing in the patient to cause irritation, blockage or physical damage. The purpose of this project is to prepare and test Y-90-containing microspheres with pre- programmed bioresorption. Glass composition range and Y-90 solubility in glasses will be established. The in vitro properties of bioresorbable Y-90 calcium phosphate glass microspheres will be characterized so that follow-up tests can be conducted in laboratory animals. Applications of Y-90 microspheres include direct intratumoral injection (infusional brachytherapy) in treatment of cancers of liver, pancreas, brain, etc., and radiation synovectomy of rheumatoid arthritis.