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INTERLEUKIN 1BETA EFECTS ON INGESTIVE BEHAVIOR

白细胞介素 1BETA 对摄取行为的影响

基本信息

批准号：
2603408
负责人：
PETER C BUTERA
金额：
$ 10.14万
依托单位：
NIAGARA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-06-01 至 2000-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2603408
关键词：
anorexia anorexic agent behavioral /social science research tag drug interactions estradiol female hormone regulation /control mechanism interleukin 1 laboratory rat nutrient intake activity nutrition related tag ovariectomy progesterone psychopharmacology

项目摘要

DESCRIPTION: This is an application for an Academic Research Enhancement Award requesting two years of support for a project to examine the influence of ovarian hormones on the suppression of food intake by the cytokine interleukin 1 beta. Interleukin 1 beta (IL-1) is a cytokine that is released by monocytes and macrophages activated during the acute phase response which occurs soon after infection or injury. IL-1 is responsible for many of the local and general responses to inflammation and also induces a constellation of symptoms known as "sickness behavior" (e.g., malaise, fatigue, decreased eating and drinking, lack of interest in usual activities). When administered to rats, IL-1 causes profound alterations in behavior including a suppression of food and water intake. Previous research provides strong evidence for sex differences in immune function and its modulation by gonadal steroids. These findings indicate that, in both human and non-human animals, females are immunologically stronger than males. Consistent with these observations are the findings that behavioral responses to IL-1 fluctuate across the rat estrous cycle. The suppressive effect of IL-1 on activity has been reported to be greater in estrus than in non-estrus females. These data indicate that the effects of IL-1 are influenced by ovarian hormones and suggest that interactions between gonadal steroids and cytokines may contribute to sex differences in immune response. The goals of this study are to evaluate the ability of estradiol and progesterone to modulate the inhibitory effects of IL-1 on ingestive behavior, a behavioral system in which ovarian hormones are known to exert strong effects. Information obtained from the proposed research will not only contribute to our understanding of how cytokines and gonadal steroids influence food intake, but also will also illustrate how interactions among the endocrine, immune, and nervous systems may contribute to sex differences in the immune response. Two sets of experiments are being proposed. In the first experiment the investigator will evaluate the ability of estradiol to augment the inhibition on food and water intake produced by different doses of IP injections of IL-1. The second experiment will examine the role of progesterone in estradiol IL-1 interactions.

描述：这是一个学术研究增强的应用程序奖项要求对一个项目提供两年的支持，以审查影响力卵巢激素对细胞因子抑制食物摄入的作用白细胞介素1 β 白细胞介素1 β（IL-1）是一种细胞因子，由急性期激活的单核细胞和巨噬细胞释放在感染或受伤后不久发生的反应。 IL-1负责对于许多局部和全身炎症反应，一系列被称为“病态行为”的症状（例如，不舒服，疲劳，饮食减少，对日常生活缺乏兴趣活动）。当给予大鼠时，IL-1会引起行为包括抑制食物和水的摄入。先前研究为免疫功能的性别差异提供了强有力的证据，它的调节通过性腺类固醇。这些发现表明，在这两个国家中，人类和非人类动物，女性的免疫力比男性强。男性。与这些观察结果相一致的是，对IL-1的反应在大鼠发情周期中波动。该抑制性据报道，IL-1对活性的影响在发情期比在发情期大。非发情期雌性。这些数据表明IL-1的作用是受卵巢激素的影响，并表明性腺激素之间的相互作用，类固醇和细胞因子可能导致免疫反应的性别差异。本研究的目的是评估雌二醇和孕酮调节IL-1对摄食的抑制作用行为，一个行为系统，其中卵巢激素是众所周知的发挥强烈的影响。从拟议研究中获得的信息不会只会帮助我们理解细胞因子和性腺类固醇影响食物摄入量，也将说明内分泌、免疫和神经系统可能导致性别差异在免疫反应中。目前正在进行两组实验。在第一个实验，研究者将评估雌二醇的能力，增强不同剂量对摄食量和饮水量的抑制作用 IP注射IL-1。第二个实验将研究孕酮在雌二醇IL-1相互作用中的作用。