DISSOCIATION OF ESTROGEN-DEPENDENT BEHAVIORS

拟议的实验将研究的功能性解离 雌激素抑制食物摄入和诱导性行为 接受性 假设这两种雌激素诱导的行为 是在不同的神经部位进行调节的。 具体来说，假设 室旁核（PVN）的雌激素刺激是 足以降低食物摄入量，但不影响生殖行为。 的 方法学将涉及用不同剂量的 17 β-雌二醇或17 α-雌二醇在不同的大脑区域，和 测量在相同的时间内食物摄入量和脊柱前凸的变化， 科目 种植体位置与行为的相关性分析 激素刺激产生的变化将被用来确定真正的 雌激素在大脑中起作用的部位。 这样一来， 能够选择性地研究一群对雌激素敏感的神经元， 主要与食欲有关，但与生殖无关， 雌二醇 未来的研究将探讨 雌激素、神经递质和控制进食的神经肽， 抑制食物雌激素的生化底物 可以更清楚地说明摄入量。 这些研究具有重要意义 对了解内分泌相关的机制的影响 饮食失调，如神经性厌食症和某些形式的肥胖。

The proposed experiments will investigate the functional dissociation of the estrogenic suppression of food intake and induction of sexual receptivity. It is hypothesized that these two estrogen-induced behaviors are mediated at different neural sites. Specifically, it is hypothesized that estrogenic stimulation of the paraventricular nucleus (PVN) is sufficient to lower food intake but not affect reproductive behavior. The methodology will involve treating ovariectomized rats with varying doses of 17 beta-estradiol or 17 alpha-estradiol in different brain regions, and measuring the changes in both food intake and lordosis in the same subjects. A correlational analysis of implant location and the behavioral changes produced by hormonal stimulation will be used to determine the true site of estrogen's actions within the brain. In this way, one would be able to selectively study a population of estrogen-sensitive neurons that are primarily involved in the appetitive, but not the reproductive, effects of estradiol. Future studies would examine the interactions between estrogens, neurotransmitters, and neuropeptides that control feeding, so that the biochemical substrate for the estrogenic suppression of food intake could be more clearly elucidated. These studies have important implications for understanding the mechanisms underlying endocrine-related eating disorders such as anorexia nervosa and some forms of obesity.