STRATEGIES FOR PREVENTION OF CLOGS IN NASOGASTRIC TUBES

鼻胃喂养管，由于其非侵入性，是首选 在疗养院和重症监护室进行长期和短期喂养 单位。饲喂管在不可预测的时间内堵塞及其 随后移除和放置新管子涉及到相当大的 费用很高，而且有可能对病人造成创伤。人们认为， 由于检查来自胃部的残留物是酸性的， 酸性pH导致酪蛋白凝结，并在墙上形成生物膜。我们 现在发现了除了蛋白质吸附之外的另一个因素，即 可能会加速堵塞现象。这些是各种各样的微生物 它们靠丰富的营养茁壮成长，并在饲喂管壁上定居 很重。一些微生物在24-48小时内凝结饲料配方。这个 第一阶段将检查将a)阻止或延缓蛋白质的涂层 己酸酯吸附和b)防止管子的微生物定植 材料。使用选定的临床分离株作为感染的特邀反应堆 物种将被用来研究堵塞现象。我们将研究 酸性饲料配方在涂布和未涂布饲料上的蛋白质粘附性 管子。 建议的商业应用： 市场规模：美国--6500万至1亿美元。国际--4000万至6500万美元。 产品：小口径饲料管、胃造瘘管。卖 价格：小口径进料管，每根13至18美元。胃造口管30美元至 每个75美元。

Nasogastric feeding tubes, due to their non-invasive nature are preferred for the long and short term feeding in nursing homes and intensive care units. Occlusion of the feed tubes at unpredictable times and their subsequent removal and placement of a new tube involves considerable expense and runs the risk of trauma in the patient. It was thought that due the checking of the residuals from the stomach which is acidic, the acid pH caused caseinate to clot and buildup a biofilm on the wall. We have now identified another factor in addition to protein adsorption, that may accelerate the clogging phenomena. These are a variety of microbes that thrive on the rich nutrients and colonize the feed tube walls heavily. Some of the microbes clot the feed formula in 24-48 hrs. The phase I will examine coatings that will a) prevent or delay protein caesinate adsorption and b) prevent microbial colonization of the tube material. An invited reactor using selected clinical isolates as infecting species will be used to study the clog phenomena. We will examine the protein adhesion from the acidic feed formula on the coated and uncoated tubes. PROPOSED COMMERCIAL APPLICATION: Market Size: U.S. - $65 to 100 million. International - $40 - 65 million. Products: Small bore feeding tubes Gastrostomy feeding tubes. Selling Price: Small bore feeding tubes $13 to $18 each. Gastrostomy tubes $30 to $75 each.