NEW MATERIALS FOR URINARY CATHETERS AND STENTS

导管用于临床泌尿实践时，其他方法， 治疗阻塞和失禁失败。 理想情况下，他们应该抵制 细菌定植和钙镁矿物结壳 存款 目前使用的导管存在上述两个问题 导致感染、狭窄和患者疼痛的问题。 的 结垢是由产脲酶细菌引起的：脲酶的作用 尿素导致氨的产生，导致尿液pH值升高。 碱性pH引起钙的沉淀和共沉淀 镁产品。 在该提案中提出了共价连接一些 强大的反应性有机官能团将a）使脲酶失活， B）防止磷酸钙和磷酸镁沉淀， pH升高和c）防止细菌粘附。 这些有机 功能性将被结合在表面层上， 导尿管 不同的改性表面将在体外试验中进行测试。 在感染和非感染中使用人尿的结壳室 长时间的模式。 这些实验的结果将 用于开发抗结垢的泌尿导管。

Catheters are used in clinical urological practice when other methods of managing obstruction and incontinence fail. Ideally, they should resist bacterial colonization and encrustation of calcium and magnesium mineral deposits. The catheters presently in use suffer from the above two problems causing infections, strictures and pain to the patients. The encrustation is caused by urease producing bacteria: the action of urease on urea results in ammonia production, resulting in increased urine pH. Alkaline pH causes the precipitation of calcium and co-precipitated magnesium products. Ideas are presented in this proposal for covalently attaching some powerful reactive organic functionalities that will a) deactivate urease, b) prevent the calcium and magnesium phosphate precipitation even if the pH rises and c) prevent bacterial adherence. These organic functionalities will be incorporated on the surface layers of the catheter. Different modified surfaces will be tested in an in vitro encrustation chamber using human urine in the infected and non-infected modes for extended periods of time. The results of these experiments will be used to develop an encrustation resistant urological catheter.