A new molecular machine required for bacterial development into spores

细菌发育成孢子所需的新分子机器

• 批准号: DP190100793
• 负责人: Dr Christopher Rodrigues
• 金额: $ 30.88万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-06-19 至 2022-06-18
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190100793
• 关键词: new; molecular; machine; required; bacterial

This project aims to provide new knowledge on how bacteria produce dormant, stress-resistant cells called spores, and how bacteria transport molecules across their cellular layers to execute biological functions. Spores can act as a source of new and recurring infections in many bacterial pathogens. This project expects to reveal molecular details on a new class of nanomachines required for spore development. The new knowledge generated may expand the arsenal of molecular targets required to develop strategies interfering with spore formation. This provides a platform from which industry could attract investment for exploring innovative strategies for controlling bacteria.

该项目旨在提供有关细菌如何产生休眠的抗应激细胞（称为孢子）以及细菌如何在细胞层中运输分子以执行生物功能的新知识。孢子可以作为许多细菌病原体中新的和复发性感染的来源。该项目预计将揭示孢子发育所需的一类新型纳米机器的分子细节。所产生的新知识可能会扩大所需的分子靶库，以制定干预孢子形成的策略。这提供了一个平台，工业界可以从中吸引投资，探索控制细菌的创新战略。