ACOUSTIC DISTORTION AND COCHLEAR STATUS

本研究的总体目标是探索失真的极限 产品耳声发射（DPOAE）测量，并确定 DPOAE参数与人类耳蜗损伤的关系 这 一般目标将在一系列实验中解决， 主要的问题是（1）如何以及可以存在和规模的 DPOAE能预测听力损失吗？(2)耳蜗 一个频率区域的损伤会影响其他频率区域的DPOAE测量 区域？(3)在低频测量的DPOAE能量比 高频率和影响这一结果的因素是什么：;（4） 正常耳DPOAE潜伏期的测量是否取决于强度， 它们在受损的耳朵中缩短，反映了非线性行为的损失”; (5)DPOAE滤波器的形状和/或位置是否受听力影响 损失 统计学原理，其中许多已应用于临床 其他医学学科中的决定（即，放射学），将在此使用 来评估这些数据。 在回答上述问题时， 致力于听力损失患者的大规模研究， 旨在提供有助于确定最佳 测试性能的条件，以及应提供 更深入地了解人类耳蜗处理的各个方面。 这些 研究最终可能导致技术的发展， 更好地了解耳蜗听力损失的后果， 人类，发生在大约2200万美国公民身上。

The overall goal of this research is to explore the limits of distortion product otoacoustic emissions (DPOAE) measurements and to determine the relation between DPOAE parameters and cochlear damage in humans. This general goal will be addressed in a series of experiments in which the primary questions are (1) how well can the presence and magnitude of hearing loss be predicted from DPOAE measurements?; (2) does cochlear damage in one frequency region influence DPOAE measurements from other regions?; (3) is less DPOAE energy measured in the low frequencies compared to high frequencies and what are the factors affecting this outcome:; (4) do measures of DPOAE latencies in normal ears depend on intensity and do they shorten in impaired ears, reflecting the loss in nonlinear behavior"; (5) is the shape and/or location of the DPOAE filter affected by hearing loss. Statistical principles, many of which have been applied to clinical decisions in other medical disciplines (i.e., radiology), will be used here to evaluate these data. In answering the above questions, efforts will be devoted to large scale studies in patients with hearing loss, to projects designed to provide information that will help to determine the optimum conditions for test performance, and to projects that should provide greater insight into aspects of cochlear processing in humans. These studies eventually may lead to the development of techniques that result in a greater understanding of the consequences of cochlear hearing loss in humans, which occurs in approximately 22 million U.S. citizens.