INTERVENTIONS TO IMPROVE MEMORY IN PATIENTS WITH MS

描述（改编自研究者摘要）：认知功能障碍是 多发性硬化症（MS）残疾的主要原因之一， 巨大的社会经济和人际关系代价。不幸的是，前 试图恢复MS中的认知功能障碍， 成功研究人员打算克服以前的局限性， 研究：1）测试干预措施的有效性， 认知功能;和2）利用一种新的结果测量， 对发生的认知功能障碍更敏感， 所提出的实验将确定多奈哌齐的功效 治疗和葡萄糖给药以增强 研究人员还将测量次要结果， 评估认知功能障碍的其它区域（即，非语言记忆， 概念思维、处理速度），这可能会通过干预得到改善。

DESCRIPTION (adapted from investigator's abstract): Cognitive dysfunction is one of the leading causes of disability in multiple scelerosis (MS), exacting a tremendous socioeconomic and interpersonal toll. Unfortunately, previous attempts to rehabilitate cognitive dysfunction in MS have had only limited success. The investigators intend to overcome the limitations of previous studies by: 1) testing the efficacy of interventions that specifically target cognitive functioning; and 2) utilizing a novel outcome measurement that may be more sensitive and ecologically valid for the cognitive dysfunction that occurs in MS. The proposed experiments will determine the efficacy of donepezil therapy and glucose administration for enhancing memory functioning in individuals with MS. The investigators will also measure secondary outcomes assessing other areas of cognitive dysfunction (i.e., nonverbal memory, conceptual thinking, processing speed) which may improve with intervention.