ACUPUNCTURE IN THE TREATMENT OF DEPRESSION

针灸治疗抑郁症

• 批准号: 2890922
• 负责人: JOHN J. ALLEN
• 金额: $ 31.26万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2890922
• 关键词: acupuncture /acupressure; alternative medicine; behavioral /social science research tag; case history; clinical depression; clinical research; clinical trials; human subject; human therapy evaluation; longitudinal human study; major depression; outcomes research; quality of life; relapse /recurrence

DESCRIPTION (Applicant's Abstract): Depression is an unfortunately common condition for which people often seek alternative (non-western) treatments, perhaps because conventional treatments do not consistently provide lasting relief. A pilot study (Allen, Schnyer, & Hitt, 1996) suggests that acupuncture, a popular but under-researched alternative treatment derived from Chinese medicine, holds sufficient promise as a treatment for depression to warrant a larger-scale clinical trial. We propose to test the efficacy acupuncture designed specifically to treat depression by comparing it to acupuncture treatment designed to treat symptoms that are not part of the depressive symptom picture and to a wait list control group. Because relapse and recurrence of Major Depression are quite common, we also propose to assess the clinical status of participants for 18 months after treatment concludes, to examine whether the dose of treatment predicts the likelihood of relapse or recurrence. In the first phase of this double-blind randomized clinical trial, 150 men and women meeting DSM-IV criteria for Major Depression will be randomly assigned to one of three conditions: (a) eight weeks of acupuncture designed specifically to address depression; (b) eight weeks of nonspecific acupuncture treatments designed to treat valid symptom pattens other than depression; (c) or a waitlist control condition. At the end of this first phase, blind assessments will be used to compare treatment effects from the perspectives of both western psychiatry and Chinese medicine. After this phase, all participants will receive specific treatment. This experimental design will thus address the following specific aims: (1) to evaluate the efficacy of acupuncture treatments for Major Depression relative to both a waitlist control and to nonspecific acupuncture treatments desired to treat symptoms that are not part of depression; (2) to evaluate the clinical significance of acupuncture as a treatment for Major Depression by assessing the impact of acupuncture not only on depression but also on functioning in social and work arenas; and (3) to examine whether a dose-response relationship exists, such that the number of specific acupuncture treatments is related to the likelihood of remission during treatment, or the likelihood of recurrence or relapse following treatment. Secondary aims are: (1) to assess the efficacy of acupuncture treatments using measures of outcome derived from the principles of Chinese medicine; (2) to examine the convergence of western-based and Chinese-medicine-based outcome measures in terms of clinical significance; (3) to determine whether changes in energetic pattern mediate changes in western defined depression severity; and (4) to explore whether patient and history variables predict response to acupuncture treatments.

描述（申请人的摘要）： 不幸的是，抑郁症是一种常见病症，人们经常寻求治疗 替代（非西方）治疗，也许是因为传统的 治疗并不能始终如一地提供持久的缓解。试点研究 （Allen、Schnyer 和 Hitt，1996）表明针灸是一种流行但 来自中医的替代疗法研究不足，认为 作为抑郁症的治疗方法有足够的前景，值得更大规模的研究 临床试验。我们建议测试所设计的针灸功效 通过与针灸治疗进行比较来专门治疗抑郁症 旨在治疗不属于抑郁症状的症状 图片和等待名单对照组。因为复发和复发 重度抑郁症很常见，我们还建议评估临床 治疗结束后 18 个月内参与者的状态，以检查 治疗剂量是否可以预测复发的可能性或 复发。在这项双盲随机临床的第一阶段 试验中，150 名符合 DSM-IV 重度抑郁症标准的男性和女性将 被随机分配到以下三种情况之一：(a) 八周 专为治疗抑郁症而设计的针灸； (b) 八周 旨在治疗有效症状模式的非特异性针灸治疗 除了抑郁症之外； (c) 或候补名单控制条件。结束时 第一阶段，将使用盲法评估来比较治疗 从西方精神病学和中国精神病学的角度来看 药品。此阶段结束后，所有参与者都将收到特定的 治疗。因此，该实验设计将解决以下问题 具体目的：（1）评价针灸治疗的疗效。 与候补名单控制和非特异性相关的重度抑郁症 需要针灸治疗来治疗不属于以下症状的症状 沮丧; (2)评价针灸治疗的临床意义 通过评估针灸的影响来治疗重度抑郁症 不仅针对抑郁症，还针对社交和工作领域的表现；和 (3) 检查是否存在剂量反应关系，使得 特定针灸治疗的次数与以下可能性有关： 治疗期间的缓解，或复发或复发的可能性 治疗后。次要目标是：（1）评估效果 使用源自原则的结果测量的针灸治疗 中医； (2) 审视西方与西方的融合 基于中医的临床意义的结果测量； (3) 确定能量模式的变化是否介导了 西方定义的抑郁症严重程度； (4) 探讨患者和 历史变量预测针灸治疗的反应。