Trait and State Frontal Brain Asymmetry in Depression

抑郁症中的特征和状态大脑额叶不对称

• 批准号: 6877180
• 负责人: JOHN J. ALLEN
• 金额: $ 33.86万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6877180
• 关键词: biomarker; brain electrical activity; case history; clinical research; depression; disease /disorder etiology; disease /disorder proneness /risk; electroencephalography; frontal lobe /cortex; gender difference; human subject; longitudinal human study; major depression; menstrual cycle; mental disorder diagnosis; serotonin inhibitor; young adult human (21-34)

DESCRIPTION (provided by applicant): Asymmetrical frontal brain activity holds promise as a marker of risk for depression. Over 40 studies suggest that resting frontal electroencephalographic (EEG) asymmetry may serve as an indicator of a trait-like diathesis to respond to emotional situations with a pattern of emotional negativity and behavioral withdrawal. Moreover, resting frontal EEG asymmetry distinguishes depressed individuals -- those currently symptomatic as well those as in remission -- from never-depressed individuals. These findings suggest that frontal EEG asymmetry is more than a correlate of a depressive episode, potentially serving as a liability marker for the development of depression. Such a marker could have prognostic and etiological value, but superimposed on the trait-like stability are fluctuations that vary as a function of occasion of assessment or experimentally manipulated emotion. Estimates of the stability of frontal EEG asymmetry are in the range of.60, suggesting that trait factors are substantial, but that variation across assessments may limit the utility of asymmetrical frontal brain activity as a trait-like risk indicator for depression. Such factors may underlie the few inconsistent findings in this literature. The present proposal represents a necessary step in the programmatic investigation of frontal EEG asymmetry as a potential risk indicator for depression, by evaluating three distinct sources of variability in frontal EEG asymmetry: 1) Stable trait consistency across multiple assessments; 2) Occasion-specific fluctuations from one assessment to the next; and, 3) State-dependent changes within a single assessment. During four visits, trait resting as well as state manipulated frontal EEG asymmetry will be assessed in depressed and nondepressed subjects. This design will allow us to address several specific aims, including: 1) To assess the relative contributions of trait, occasion, and state variance in frontal EEG asymmetry; 2) To assess whether frontal EEG asymmetry has characteristics that suggest it may profitably serve as a marker of risk for major depressive disorder; and, 3) To assess the acute impact of a widely used selective serotonin reuptake inhibitor on frontal EEG asymmetry, as medication effects have been largely unexplored. Secondary aims address methodological and treatment-related questions, as well as assessing gender and menstrual cycle effects that may moderate the relationship between frontal EEG asymmetry and depression.

描述（由申请人提供）：不对称的额叶大脑活动有望成为抑郁症风险的标志。超过 40 项研究表明，静息额叶脑电图 (EEG) 不对称性可能作为特质状素质的指标，以情绪消极和行为退缩的模式对情绪情境做出反应。此外，静息额叶脑电图不对称性可以将抑郁症患者（目前有症状的患者以及缓解期患者）与从未抑郁的患者区分开来。这些发现表明，额叶脑电图不对称不仅仅是抑郁发作的相关因素，还可能成为抑郁症发展的一个责任标志。这样的标记可能具有预后和病因学价值，但叠加在性状稳定性上的是随评估场合或实验操纵情绪而变化的波动。额叶脑电图不对称稳定性的估计值在 60​​ 范围内，这表明特质因素很重要，但评估之间的差异可能会限制不对称额叶大脑活动作为抑郁症类特质风险指标的效用。这些因素可能是该文献中少数不一致的发现的基础。本提案通过评估额叶脑电图不对称性的三个不同来源，代表了将额叶脑电图不对称性作为抑郁症潜在风险指标的程序性调查的必要步骤：1）多个评估中稳定的特征一致性； 2) 从一次评估到下一次评估的特定场合的波动； 3) 单次评估中与州相关的变化。在四次访问期间，将评估抑郁和非抑郁受试者的特质休息以及状态操纵的额叶脑电图不对称性。这种设计将使我们能够实现几个具体目标，包括：1）评估特征、场合和状态方差在额叶脑电图不对称中的相对贡献； 2) 评估额叶脑电图不对称是否具有表明其可以有效地作为重度抑郁症风险标记的特征； 3) 评估广泛使用的选择性血清素再摄取抑制剂对额叶脑电图不对称性的急性影响，因为药物作用在很大程度上尚未被探索。次要目标解决方法论和治疗相关的问题，以及评估性别和月经周期的影响，这些影响可能会缓和额叶脑电图不对称与抑郁之间的关系。