INSULIN RESISTANCE AND ATHEROSCLEROSIS STUDY (IRAS)

胰岛素抵抗和动脉粥样硬化研究(IRAS)是一项多中心研究 胰岛素抵抗与心血管疾病关系的研究进展 疾病(CVD)及其危险因素在一个三族(非裔美国人， 西班牙裔和非西班牙裔白人)人口年龄在40岁至69岁之间 基线。研究人群的选择是为了确保足够数量的 性别和葡萄糖耐量组中的参与者(正常、受损 糖耐量和非胰岛素依赖型糖尿病[NIDDM])。 IRAS是第一个包含详细信息的大型流行病学研究 胰岛素敏感性和分泌的测量。在前四年 多年的资金支持IRAS调查人员成功地设计和 实施了研究的第一阶段--对 1,626名参与者。目前的提案要求再增加五个 为未来的后续行动和复查提供多年资金 IRAS队列。所要求的资助期包括三个阶段。 在第一阶段(Y05和Y06)，调查人员建议进行 两项子研究。第一个将涉及胰岛素的测量。 NIDDM患者的敏感性。这项研究将评估四个 50例非胰岛素依赖者胰岛素敏感性测定的替代方法 志愿者。第二个分组研究将审查 三民族人群中肥胖和体脂分布的测量 在240名IRAS参与者中。此外，IRAS的所有参与者都将 每年就心血管事件和其他主要健康问题进行联系 事件。在第二阶段(Y07和Y08)，后续检查 将对IRAS队列进行评估，目标是确定 胰岛素敏感性、心血管危险因素、 动脉粥样硬化发展和心血管事件的测量 事件。此外，在前四个赛季(Y05-08)中，我们付出了很大努力 将继续致力于分析和报告交叉- 第一次IRAS检查的横断面数据。最后阶段(Y09) 将包括数据库关闭和存档，以及分析和报告 纵向结果。

The Insulin Resistance and Atherosclerosis Study (IRAS) is a multicenter study of the relationship between insulin resistance and cardiovascular disease (CVD) and its risk factors in a tri-ethnic (African-American, Hispanic, and non-Hispanic white) population aged 40 to 69 years at baseline. The study population was selected to insure adequate numbers of participants within gender and glucose tolerance groups (normal, impaired glucose tolerance, and non-insulin dependent diabetes mellitus [NIDDM]). IRAS is the first large epidemiologic study to include detailed measurements of insulin sensitivity and secretion. During the first four years of funding the IRAS investigators successfully designed and implemented the first phase of the study--a cross-sectional evaluation of 1,626 participants. The current proposal requests an additional five years of funding for the prospective follow-up and reexamination of the IRAS cohort. The requested funding period consists of three phases. During the first phase (Y05 and Y06), the investigators propose to conduct two substudies. The first will address the measurement of insulin sensitivity in individuals with NIDDM. This study will evaluate four alternative techniques for measuring insulin sensitivity in 50 non-IRAS volunteers. The second substudy will examine methodologic issues in the measurement of obesity and body fat distribution in a tri-ethnic subgroup of 240 IRAS participants. In addition, all IRAS participants will be contacted annually for incident cardiovascular and other major health events. During the second phase, (Y07 and Y08), a follow-up examination of the IRAS cohort will be conducted with the goal of determining predictors of changes in insulin sensitivity, cardiovascular risk factors, measures of atherosclerosis development, and incident cardiovascular events. Additionally, throughout the first fours (Y05-08) a major effort will continue to be devoted to the analysis and reporting of the cross- sectional data from the first IRAS examination. The final phase (Y09) will include database closure and archival, and analysis and reporting of the longitudinal results.