Childhood Misfortune and Adult Health among Black, White, and Hispanic Americans

黑人、白人和西班牙裔美国人的童年不幸和成年健康

• 批准号: 9885355
• 负责人: KENNETH F. FERRARO
• 金额: $ 82.49万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9885355
• 关键词: Accounting; Address; Adult; African American; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; American; Cardiovascular Diseases; Childhood; Chronic; Chronic Disease; Cognitive; Communities; Cost Control; Critical Pathways; Data; Development; Disease; Elderly; Ethnic group; Event; Exposure to; Financial Hardship; Health; Health and Retirement Study; Healthcare; Heart Diseases; Hispanic Americans; Hispanics; Impaired cognition; Inequality; Inflammation; Interruption; Intervention; Interview; Life; Life Cycle Stages; Life Experience; Life Style; Link; Literature; Longevity; Mediating; Mediation; Mediator of activation protein; Myocardial Ischemia; Outcome; Outcome Study; Pathway interactions; Race; Research; Resources; Risk; Smoking; Social support; Stroke; Surveys; Techniques; Testing; cardiovascular disorder risk; caucasian American; disability; early experience; early life exposure; effective intervention; epidemiology study; ethnic difference; health data; life history; physical abuse; psychologic; public health relevance; racial and ethnic; racial difference; response; social; stressor; theories

Childhood Misfortune and Adult Health among Black, White, and Hispanic Americans Project Summary/Abstract Recent epidemiologic research provides compelling evidence that negative events and experiences early in life hasten the onset and progression of numerous adult chronic diseases. Despite the growing evidence, the precise mechanisms for these relationships remain a subject of continuing debate. The purpose of this project, therefore, is to explicate mechanisms and pathways to reduce harmful health consequences of negative childhood exposures. We investigate the early origins of adult health conditions of urgent national need (cardiovascular disease and cognitive decline) as well as the propensity to grow older free of physical and cognitive impairment, which we refer to as exceptional longevity. We seek to identify resources that empower diverse groups of Americans to optimize their health and longevity, even after facing considerable misfortune early in life. We hypothesize that chronic inflammation is a critical pathway by which life course stressors exact a toll on health but that social, psychological, and community resources over the life course reduce health risks. Although most of the extant research on the topic examines White adults, the present study investigates whether the mechanisms vary for Black, White, and Hispanic Americans. Resources such as social support and health lifestyles vary across racial and ethnic communities, suggesting the value of investigating distinct mechanisms for amelioration. We use eight waves of data from the Health and Retirement Study (HRS), organized in two studies, to test hypotheses. Study 1 examines data from 19,630 adults (age 51+) in 2004 who are re-interviewed biennially, providing 14 years of observation. Study 2 uses information from 10,325 adults (age 51+) in 2010, incorporating rich data from the Life History Surveys launched in 2015. There are three specific aims: 1. To identify mediators of the relationship between childhood exposures and risk of cardiovascular diseases among Black, White, and Hispanic adults. 2. To examine the relationship between childhood exposures and cognitive decline—an early indicator of risk for Alzheimer’s Disease and Related Disorders (ADRD)—among Black, White, and Hispanic adults as well as the potential mediators of the relationship. 3. To explicate relationships between childhood exposures and exceptional longevity and identify resources that enable Black, White, and Hispanic adults to be free of both physical and cognitive impairment in later life. The hypotheses, derived from the above aims, will be tested with a variety of multivariate analytic techniques to estimate direct and indirect effects of childhood exposures on the outcomes, with formal tests of mediation and moderation.

黑人，白人和西班牙裔美国人的童年不幸和成人健康 项目摘要/摘要 最近的流行病学研究提供了令人信服的证据，表明负面事件和经验很早就 在生活中，加快了许多成年慢性疾病的发作和发展。尽管有越来越多的证据 这些关系的确切机制仍然是持续辩论的主题。这个目的 因此，项目是要阐明机制和途径，以减少有害健康后果 童年的负面暴露。 我们研究了紧急国家需求的成人健康状况的早期起源（心血管疾病） 和认知能力下降）以及承诺不再具有身体和认知障碍的年长的承诺，这 我们称为杰出的寿命。我们寻求确定赋予美国人群体的能力的资源 即使在一生早期面临考虑的遗憾之后，也可以优化其健康和寿命。我们假设 这种慢性炎症是生命过程的关键途径，这是对健康造成巨大损害的关键途径 生活过程中的社会，心理和社区资源降低了健康风险。 尽管大多数关于该主题考试的额外研究白人成年人，但本研究调查了 黑色，白人和西班牙裔美国人的机制是否有所不同。社会支持等资源 在种族和族裔社区中，健康生活方式各不相同，表明调查不同的价值 改善机制。 我们使用在两项研究中组织的健康和退休研究（HRS）的八波数据浪潮来测试 假设。研究1考试来自2004年19,630名成年人（51岁以上）的数据，他们每两年重新审视， 提供14年的观察。研究2使用来自2010年10,325名成年人（51岁以上）的信息， 结合了2015年启动的人生历史调查的丰富数据。有三个具体的目标： 1。确定儿童暴露与心血管疾病风险之间关系的调解人 在黑色，白色和西班牙裔成年人中。 2。检查儿童暴露与认知能力下降之间的关系 - 风险的早期指标 对于阿尔茨海默氏病和相关疾病（ADRD） - 黑人，白人和西班牙裔成年人 以及这种关系的潜在调解人。 3。要在童年暴露与特殊寿命之间的明确关系并确定资源 这使黑人，白人和西班牙裔成年人能够摆脱身体和认知障碍 以后的生活。 从上述目的得出的假设将通过多种多元分析进行测试 估计儿童暴露对结果的直接和间接影响的技术，并通过正式测试 调解和节制。

项目成果

Disciplinary Roots of 300 Top-Ranked Scientific Contributors to Gerontology: From Legacy to Enriching Our Discovery.

300 位老年学顶级科学贡献者的学科根源：从遗产到丰富我们的发现。

• DOI: 10.1093/gerona/glac129
• 发表时间: 2022
• 期刊: The journals of gerontology. Series A, Biological sciences and medical sciences
• 作者: Ferraro,KennethF

Racial-Ethnic Disparities in Dual-Function Life Expectancy.

双功能预期寿命的种族差异。

• DOI: 10.1093/gerona/glad059
• 发表时间: 2023
• 期刊: The journals of gerontology. Series A, Biological sciences and medical sciences
• 作者: Bauldry,Shawn;Thomas,PatriciaA;Sauerteig-Rolston,MadisonR;Ferraro,KennethF
• 通讯作者: Ferraro,KennethF