TOMOSYNTHESIS FOR IMPROVED PULMONARY NODULE DETECTION

用于改进肺结节检测的断层合成

基本信息

  • 批准号:
    2901910
  • 负责人:
  • 金额:
    $ 32.59万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1999
  • 资助国家:
    美国
  • 起止时间:
    1999-08-06 至 2002-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (Adapted from Applicant's Abstract): The purpose of these studies is to develop and evaluate a method for improving clinical detection of pulmonary nodules, using a technique known as digital tomosynthesis. Digital augments a conventional chest exam by providing three-dimensional information through a series of longitudinal slice images. These slice images are reconstructed from a set of discrete projection images acquired at different angles, using a conventional x-ray tube and a new digital flat-panel x-ray detector. The tomosynthesized images may be viewed slice-by-slice or as a 3-D volume-rendered projection in a "virtual fluoroscopy" viewing environment. The diagnostic benefit of tomosynthesis is the use of 3-D information to improve detection and discrimination of pulmonary nodules by eliminating the confusion of overlying structures. CT would remain the gold-standard for clinical workup once nodules are detected, with tomosynthesis providing a low-dose/low-cost method for improving initial detection accuracy. Clinically the tomosynthesis images would be acquired whenever a digital PA/lateral chest exam is scheduled, but with the lateral image acquired at half the conventional exposure level. The results, using the new flat-panel detector, would be a PA film with improved image quality, a lateral with conventional image quality, and a three-dimensional tomosynthesis data set, all acquired at an overall exposure comparable to a standard screen-film PA/lateral chest exam. Three different tomosynthesis algorithms will be investigated in this proposal: traditional shift-and-add tomosynthesis, a Tuned Aperture Computed Tomography (TACT) algorithm with improved registration of images, and a Matrix Inversion Tomosynthesis (MITS) algorithm for improved elimination of residual blurring from structures not in the plane of interest. The specific aims of the project include: construction of a digital tomosynthesis chest system; improvement of the MITS algorithm; development of a three-dimensional viewing environment; optimization of image acquisition geometry; evaluation of tomosynthesis artifacts; optimization of patient dose; comparison of MITS, TACT, and "conventional" tomosynthesis; and a clinical test of the hypothesis that tomosynthesis improves the detection of pulmonary nodules over what is possible with conventional radiography.
描述(改编自申请人摘要):这些研究的目的

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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JAMES T DOBBINS其他文献

JAMES T DOBBINS的其他文献

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{{ truncateString('JAMES T DOBBINS', 18)}}的其他基金

Cross-disciplinary Training in Medical Physics
医学物理跨学科培训
  • 批准号:
    7233336
  • 财政年份:
    2007
  • 资助金额:
    $ 32.59万
  • 项目类别:
Cross-disciplinary Training in Medical Physics
医学物理跨学科培训
  • 批准号:
    7440318
  • 财政年份:
    2007
  • 资助金额:
    $ 32.59万
  • 项目类别:
Cross-disciplinary Training in Medical Physics
医学物理跨学科培训
  • 批准号:
    7870413
  • 财政年份:
    2007
  • 资助金额:
    $ 32.59万
  • 项目类别:
Cross-disciplinary Training in Medical Physics
医学物理跨学科培训
  • 批准号:
    7609067
  • 财政年份:
    2007
  • 资助金额:
    $ 32.59万
  • 项目类别:
Cross-disciplinary Training in Medical Physics
医学物理跨学科培训
  • 批准号:
    8076822
  • 财政年份:
    2007
  • 资助金额:
    $ 32.59万
  • 项目类别:
TOMOSYNTHESIS FOR IMPROVED PULMONARY NODULE DETECTION
用于改进肺结节检测的断层合成
  • 批准号:
    6377030
  • 财政年份:
    1999
  • 资助金额:
    $ 32.59万
  • 项目类别:
TOMOSYNTHESIS FOR IMPROVED PULMONARY NODULE DETECTION
用于改进肺结节检测的断层合成
  • 批准号:
    6174245
  • 财政年份:
    1999
  • 资助金额:
    $ 32.59万
  • 项目类别:
Tomosynthesis for improved pulmonary nodule detection
用于改进肺结节检测的断层合成
  • 批准号:
    6543161
  • 财政年份:
    1998
  • 资助金额:
    $ 32.59万
  • 项目类别:
Tomosynthesis for improved pulmonary nodule detection
用于改进肺结节检测的断层合成
  • 批准号:
    6783357
  • 财政年份:
    1998
  • 资助金额:
    $ 32.59万
  • 项目类别:
Tomosynthesis for improved pulmonary nodule detection
用于改进肺结节检测的断层合成
  • 批准号:
    6647103
  • 财政年份:
    1998
  • 资助金额:
    $ 32.59万
  • 项目类别:

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