TOMOSYNTHESIS FOR IMPROVED PULMONARY NODULE DETECTION
用于改进肺结节检测的断层合成
基本信息
- 批准号:6174245
- 负责人:
- 金额:$ 30.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-08-06 至 2002-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (Adapted from Applicant's Abstract): The purpose of these studies
is to develop and evaluate a method for improving clinical detection of
pulmonary nodules, using a technique known as digital tomosynthesis. Digital
augments a conventional chest exam by providing three-dimensional information
through a series of longitudinal slice images. These slice images are
reconstructed from a set of discrete projection images acquired at different
angles, using a conventional x-ray tube and a new digital flat-panel x-ray
detector. The tomosynthesized images may be viewed slice-by-slice or as a 3-D
volume-rendered projection in a "virtual fluoroscopy" viewing environment. The
diagnostic benefit of tomosynthesis is the use of 3-D information to improve
detection and discrimination of pulmonary nodules by eliminating the confusion
of overlying structures. CT would remain the gold-standard for clinical workup
once nodules are detected, with tomosynthesis providing a low-dose/low-cost
method for improving initial detection accuracy. Clinically the tomosynthesis
images would be acquired whenever a digital PA/lateral chest exam is scheduled,
but with the lateral image acquired at half the conventional exposure level.
The results, using the new flat-panel detector, would be a PA film with
improved image quality, a lateral with conventional image quality, and a
three-dimensional tomosynthesis data set, all acquired at an overall exposure
comparable to a standard screen-film PA/lateral chest exam. Three different
tomosynthesis algorithms will be investigated in this proposal: traditional
shift-and-add tomosynthesis, a Tuned Aperture Computed Tomography (TACT)
algorithm with improved registration of images, and a Matrix Inversion
Tomosynthesis (MITS) algorithm for improved elimination of residual blurring
from structures not in the plane of interest. The specific aims of the project
include: construction of a digital tomosynthesis chest system; improvement of
the MITS algorithm; development of a three-dimensional viewing environment;
optimization of image acquisition geometry; evaluation of tomosynthesis
artifacts; optimization of patient dose; comparison of MITS, TACT, and
"conventional" tomosynthesis; and a clinical test of the hypothesis that
tomosynthesis improves the detection of pulmonary nodules over what is possible
with conventional radiography.
描述(改编自申请人摘要):这些研究的目的
目的是开发和评估一种方法,
肺结节,使用数字断层合成技术。数字
通过提供三维信息来增强传统的胸部检查
通过一系列纵向切片图像。这些切片图像是
从在不同的时间点采集的一组离散投影图像重建
角度,使用传统的X射线管和新的数字平板X射线
检测器断层合成的图像可以被逐切片地观察或作为3D图像被观察。
在“虚拟荧光透视”观察环境中的体绘制投影。的
断层合成的诊断益处是使用3D信息来改善
通过消除混淆来检测和区分肺结节
覆盖结构。CT仍将是临床检查的金标准
一旦检测到结节,断层合成提供低剂量/低成本
提高初始检测精度的方法。在临床上,
无论何时安排数字PA/侧胸检查都将采集图像,
但是以常规曝光水平的一半获取横向图像。
结果,使用新的平板探测器,将是一个PA膜,
改善的图像质量,具有传统图像质量的侧面,以及
三维断层合成数据集,全部在整体曝光下采集
与标准屏-片PA/侧位胸部检查相当。三种不同的
断层合成算法将研究在这个建议:传统的
平移相加断层合成,一种调谐孔径计算机断层成像(TACT)
算法与改进的图像配准,和一个矩阵求逆
用于改进的残余模糊消除的层析合成(MITS)算法
不在目标平面内的结构。项目的具体目标
包括:构建数字断层合成胸部系统;改进
MITS算法;三维观察环境的开发;
图像采集几何结构的优化;断层合成的评价
伪影;患者剂量优化; MITS、TACT和
“常规”断层合成;以及对以下假设的临床测试,
X射线断层合成技术提高了肺结节的检测,
用传统的放射线照相术。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JAMES T DOBBINS其他文献
JAMES T DOBBINS的其他文献
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{{ truncateString('JAMES T DOBBINS', 18)}}的其他基金
TOMOSYNTHESIS FOR IMPROVED PULMONARY NODULE DETECTION
用于改进肺结节检测的断层合成
- 批准号:
6377030 - 财政年份:1999
- 资助金额:
$ 30.87万 - 项目类别:
TOMOSYNTHESIS FOR IMPROVED PULMONARY NODULE DETECTION
用于改进肺结节检测的断层合成
- 批准号:
2901910 - 财政年份:1999
- 资助金额:
$ 30.87万 - 项目类别:
Tomosynthesis for improved pulmonary nodule detection
用于改进肺结节检测的断层合成
- 批准号:
6543161 - 财政年份:1998
- 资助金额:
$ 30.87万 - 项目类别:
Tomosynthesis for improved pulmonary nodule detection
用于改进肺结节检测的断层合成
- 批准号:
6783357 - 财政年份:1998
- 资助金额:
$ 30.87万 - 项目类别:
Tomosynthesis for improved pulmonary nodule detection
用于改进肺结节检测的断层合成
- 批准号:
6647103 - 财政年份:1998
- 资助金额:
$ 30.87万 - 项目类别:
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