PESTICIDES AND VDJ-RECOMBINASE MUTATIONS IN CHILD NHL

描述：(改编自《调查者摘要》)接触杀虫剂是 与成人患淋巴瘤和白血病的风险增加有关。这个 儿童癌症组织(CCG)最近发现非霍奇金淋巴瘤(NHL) 孩子和父母与农药接触有关。这个 染色体效应似乎是由于 VDJ-重组酶系统与编码的基因组重排相关 免疫球蛋白和T细胞受体蛋白。这些重新安排是 接触杀虫剂的农业工人人数增加。 本申请拟对儿童非霍奇金淋巴瘤进行病例对照研究 (600例新诊断的未指明性别的病例)(1)确认 农药暴露风险增加，识别农药类型 负责，并确定子宫内与子宫内的相对重要性 儿童期接触，以及(2)使用两种异常的血液生物标志物 VDJ-重组酶活性用于判断儿童NHL是否有较高的 重组率高于对照组，以及这些频率是否 与杀虫剂(前)、其他环境暴露(前)和 化疗效果(治疗后)。将有两个匹配的对照组 标识和社区控制(随机数字拨号)和控制 通过案件的治疗机构确认。调查人员 声明结果可能与儿童白血病相关，因为 和淋巴瘤一样，也可能与这些恶性肿瘤有关 成年人。

DESCRIPTION: (Adapted from Investigator's Abstract) Pesticide exposures are associated with increased risk of lymphoma and leukemia in adults. The Children's Cancer Group (CCG) recently found non-Hodgkin's lymphoma (NHL) in the child and parent to be associated with pesticide exposure. The chromosomal effects appear to be due to aberrant action of the VDJ-recombinase system relative to rearrangements of the genome coding for immunoglobulins and T-cell receptor proteins. These rearrangements were increased in pesticide-exposed agricultural workers. This application proposes to conduct a case-control study of childhood NHL (600 newly-diagnosed cases of unspecified gender) to (1) confirm the elevated risk with pesticide exposure, identify the types of pesticides responsible, and determine the relative importance of in utero versus childhood exposure, and (2) use two blood biomarkers of aberrant VDJ-recombinase activity to determine whether children with NHL have higher rates of recombination than control subjects, and whether these frequencies correlate with pesticides (pre-), other environmental exposures (pre-), and effectiveness of chemotherapy (post-). Two matched control groups will be identified and a community control (random digit dialing) and a control ascertained through the case's treating institution. The investigators state that the results will be potentially relevant to childhood leukemia as well as lymphoma, and may also have implications for these malignancies in adults.