CORE--CHILDHOOD CANCER

核心——儿童癌症

• 批准号: 6587867
• 负责人: Jonathan Buckley
• 金额: $ 11.79万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6587867
• 关键词: biomedical facility; carbopolycyclic compound; clinical research; electromagnetic radiation; environment related neoplasm /cancer; environmental health; environmental toxicology; human subject; interview; metal poisoning; neoplasm /cancer epidemiology; occupational hazard; passive smoking; pediatric neoplasm /cancer; pesticides; questionnaires; radon; solvents

Members of the Childhood Cancer Research Core have conducted, or collaborated on numerous studies that have addressed questions relating to home or parental occupational exposures. The exposures of interest are wide-ranging, but have included pesticides, polynuclear aromatic hydrocarbons (PAHs), metals, radon, electromagnetic fields (EMF), environmental tobacco smoke (ETS), infectious agents, N-nitroso compounds, and solvents. The mainstay of these studies continues to be data collection through self-administered questionnaires or (more commonly) interviews of the parents of children with specific cancers and a matched control group. This approach is cost-effective. However, the Core members recognize the potential of the new molecular techniques to provide insights into the processes of tumorogenesis and/or to quantitate in-vivo exposure to environmental insult, and the need to do so on a cost-effective basis in large epidemiological studies. The Core is just starting a case-control study of non-Hodgkin?s lymphoma in children that will assess pesticide exposure and will measure the frequency of two specific chromosomal rearrangements mediated by the VDJ recombinase enzyme system.

儿童癌症研究中心的成员进行了，或 合作进行了许多研究， 家庭或父母职业暴露。感兴趣的风险范围很广， 还包括杀虫剂多环芳烃 多环芳烃、金属、氡、电磁场、环境烟草 烟雾（ETS）、传染性病原体、N-亚硝基化合物和溶剂。 这些研究的主体仍然是通过自我管理的数据收集。 调查问卷或（更常见的）对父母的采访， 患有特定癌症的儿童和匹配的对照组。这种方法 性价比然而，核心成员认识到新的 利用分子技术深入了解肿瘤发生的过程 和/或定量体内暴露于环境损害，以及需要 在大型流行病学研究中以成本效益为基础这样做。核心是 刚开始非霍奇金淋巴瘤的病例对照研究儿童S淋巴瘤， 将评估农药暴露，并将测量两个特定的频率， VDJ重组酶系统介导的染色体重排。