CORE--CHILDHOOD CANCER

核心——儿童癌症

• 批准号: 6564409
• 负责人: Jonathan Buckley
• 金额: $ 11.79万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-02 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6564409
• 关键词: biomedical facility; carbopolycyclic compound; clinical research; electromagnetic radiation; environment related neoplasm /cancer; environmental health; environmental toxicology; human subject; interview; metal poisoning; neoplasm /cancer epidemiology; occupational hazard; passive smoking; pediatric neoplasm /cancer; pesticides; questionnaires; radon; solvents

Description: Members of the Childhood Cancer Research Core have conducted, or collaborated on numerous studies that have addressed questions relating to home or parental occupational exposures. The exposures of interest are wide-ranging, but have included pesticides, polynuclear aromatic hydrocarbons (PAHs), metals, radon, electromagnetic fields (EMF), environmental tobacco smoke (ETS), infectious agents, N-nitroso compounds, and solvents. The mainstay of these studies continues to be data collection through self-administered questionnaires or (more commonly) interviews of the parents of children with specific cancers and a matched control group. This approach is cost-effective. However, the Core members recognize the potential of the new molecular techniques to provide insights into the processes of tumorogenesis and/or to quantitate in-vivo exposure to environmental insult, and the need to do so on a cost-effective basis in large epidemiological studies. The Core is just starting a case-control study of non-Hodgkin's lymphoma in children that will assess pesticide exposure and will measure the frequency of two specific chromosomal rearrangements mediated by the VDJ recombinase enzyme system.

描述：儿童癌症研究核心的成员进行过，或 合作进行了大量研究，这些研究解决了与 家庭或父母的职业暴露。感兴趣的风险敞口很广， 但包括杀虫剂、多环芳香烃 (PAHs)、金属、氡、电磁场(EMF)、环境烟草 烟雾(ETS)、感染剂、N-亚硝基化合物和溶剂。 这些研究的主要内容仍然是通过自我管理收集数据 对父母的问卷调查或(更常见的)访谈 患有特定癌症的儿童和匹配的对照组。这种方法是 性价比高。然而，核心成员认识到新的 分子技术为肿瘤发生过程提供洞察力 和/或量化体内暴露于环境侮辱的情况，以及 在大型流行病学研究中，这是在成本效益的基础上进行的。核心是 刚刚开始一项关于儿童非霍奇金淋巴瘤的病例对照研究 将评估农药暴露并将测量两种特定的 VDJ重组酶系统介导的染色体重排。