CORE--CHILDHOOD CANCER

核心——儿童癌症

• 批准号: 6667475
• 负责人: Jonathan Buckley
• 金额: $ 11.79万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6667475
• 关键词: biomedical facility; carbopolycyclic compound; clinical research; electromagnetic radiation; environment related neoplasm /cancer; environmental health; environmental toxicology; human subject; interview; metal poisoning; neoplasm /cancer epidemiology; occupational hazard; passive smoking; pediatric neoplasm /cancer; pesticides; questionnaires; radon; solvents

Members of the Childhood Cancer Research Core have conducted, or collaborated on numerous studies that have addressed questions relating to home or parental occupational exposures. The exposures of interest are wide-ranging, but have included pesticides, polynuclear aromatic hydrocarbons (PAHs), metals, radon, electromagnetic fields (EMF), environmental tobacco smoke (ETS), infectious agents, N-nitroso compounds, and solvents. The mainstay of these studies continues to be data collection through self-administered questionnaires or (more commonly) interviews of the parents of children with specific cancers and a matched control group. This approach is cost-effective. However, the Core members recognize the potential of the new molecular techniques to provide insights into the processes of tumorogenesis and/or to quantitate in-vivo exposure to environmental insult, and the need to do so on a cost-effective basis in large epidemiological studies. The Core is just starting a case-control study of non-Hodgkin?s lymphoma in children that will assess pesticide exposure and will measure the frequency of two specific chromosomal rearrangements mediated by the VDJ recombinase enzyme system.

儿童癌症研究中心的成员进行了，或者