Elucidating the roles of steroid receptors in mitochondria

阐明线粒体中类固醇受体的作用

• 批准号: DP190100091
• 负责人: Prof Phil Hansbro
• 金额: $ 31.06万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-08-26 至 2023-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190100091
• 关键词: Elucidating; roles; steroid; receptors; mitochondria

This project aims to elucidate the roles of newly discovered steroid receptors in the functions of mitochondria. The project will characterise their impact on cellular respiration, oxidative stress, and the induction of inflammation. By defining these processes in the healthy state and in response to common environmental challenges of infection and smoke exposure, the project will characterise the fundamental biology of entirely new processes of how normal body hormones and administered steroids may function. This may eventually lead to new and more effective ways to control inflammation that will have significant benefits to mammalian health and improve health care and agriculture outcomes.

本项目旨在阐明新发现的类固醇受体在线粒体功能中的作用。该项目将研究它们对细胞呼吸、氧化应激和炎症诱导的影响。通过在健康状态下定义这些过程，并应对感染和烟雾暴露的常见环境挑战，该项目将揭示正常身体激素和类固醇如何发挥作用的全新过程的基础生物学。这可能最终导致新的和更有效的方法来控制炎症，这将对哺乳动物的健康有显着的好处，并改善医疗保健和农业成果。