New guardians of the mucosa: Molecular characterisation of M cell biology

粘膜的新守护者：M 细胞生物学的分子特征

• 批准号: DP200101058
• 负责人: Prof Phil Hansbro
• 金额: $ 35.12万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200101058
• 关键词: New; guardians; mucosa; Molecular; characterisation

We aim to completely define the cellular and molecular biology of gut and lung M cells for the first time. We will elucidate how they develop, are regulated and function at a molecular level, and how M cells maintain normal gut and lung tissues and induce immune responses to protect against microbial challenges. In the future, the new insights will be essential pre-requisites for the development of mucosal-based interventions and vaccines that protect the gut and lung from infectious and inflammatory issues. The harnessing of effective immune responses to control such challenges, are of enormous fundamental and long-standing biological interest, and are amongst the most important areas of current scientific research.

我们的目标是首次完全定义肠道和肺M细胞的细胞和分子生物学。我们将阐明它们如何在分子水平上发展，调节和发挥作用，以及M细胞如何维持正常的肠道和肺组织并诱导免疫反应以抵御微生物的挑战。在未来，这些新的见解将成为开发基于粘膜的干预措施和疫苗以保护肠道和肺部免受感染和炎症问题的重要先决条件。利用有效的免疫应答来控制这些挑战具有巨大的基本和长期的生物学意义，并且是当前科学研究的最重要领域之一。