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ATM AND CELL DEATH IN THE NERVOUS SYSTEM

ATM AND CELL DEATH IN THE NERVOUS SYSTEM
神经系统中的 ATM 和细胞死亡
批准号：
2705246
负责人：
PETER J MCKINNON
金额：
$19.81万
依托单位：
ST. JUDE CHILDREN'S RESEARCH HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-08-01 至 2002-07-31
来源：
https://reporter.nih.gov/project-details/2705246
关键词：
BCL2 gene /protein animal genetic material tag apoptosis ataxia telangiectasia cerebral ischemia /hypoxia developmental genetics developmental neurobiology disease /disorder etiology embryo /fetus embryo /fetus toxicology gene induction /repression genetically modified animals ionizing radiation kainate laboratory mouse neurogenetics neurons neurotoxicology nitrous oxide oxidative stress tissue /cell culture tumor suppressor proteins

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DESCRIPTION: This is a new proposal, the intention is to investigate At, regulated apoptosis with the ultimate goal of elucidating downstream effectors of Atm signaling. The proposal is based on preliminary data indicating that specific populations of dividing cells in the Atm knockout nervous system are protected from the pro-apoptotic effects of ionizing radiation. The aims of the application will be to identify potential physiologically relevant activators (oxidative stress, excitotoxicity, axotomy) of the Atm signaling pathway by using Atm -/- mice and neuronal cell cultures derived from these animals; to identify components of the apoptotic pathway involving Atm and the nervous system by using the Atm -/- mice as well as p53, Bcl-2 and Bax -/- mice, and cultures derived from these animals and finally, to exhaustively investigate and characterize the developing nervous system in the Atm -/- mice and to ask whether Atm is important for normal programmed cell death.
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