Third Genome Dynamics in the Neurosciences Conference

神经科学会议上的第三届基因组动力学

• 批准号: 7806347
• 负责人: PETER J MCKINNON
• 金额: $ 3.2万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7806347
• 关键词: Address; Age; Aging; Alzheimer' s Disease; Area; Brain; Cells; Clinical; Commit; Computer Systems Development; DNA; DNA Damage; DNA Repair; DNA Repair Disorder; Data; Development; Disease; Employee Strikes; Etiology; Fostering; Functional disorder; Genome; Genome Stability; Genomics; Genotoxic Stress; Homeostasis; Immune system; International; Intervention; Journals; Laboratories; Lead; Lesion; Link; Maintenance; Mitochondria; Mutation; Nervous system structure; Neurodegenerative Disorders; Neurologic; Neurons; Neurosciences; Nuclear; Oral; Parkinson Disease; Pathology; Patients; Postdoctoral Fellow; Prevention; Process; Publishing; Research; Research Personnel; Role; Scientist; Series; Signal Transduction; Students; Syndrome; United States; Weight; Work; abstracting; age related; aging brain; aging population; base; carcinogenesis; career; design; graduate student; human disease; insight; interest; meetings; nervous system development; nervous system disorder; neurodevelopment; neuropathology; next generation; normal aging; programs; relating to nervous system; repaired; response; symposium; therapy design

DESCRIPTION (provided by applicant): The response to genotoxic stress is a prerequisite for development of the nervous system. Mutations in a variety of DNA repair or DNA damage-response factors can lead to human diseases that are characterized by pronounced neuropathology. In many of these syndromes the neurological component is amongst the most deleterious aspects of the disease. Despite the importance of genomic integrity in the nervous system, there is a striking lack of a focused series of meetings that explore the roles for the DNA damage response in the nervous system. Although clearly recognized as key factors in neurological disease, discussions of DNA repair and DNA damage signaling at scientific meetings have been heavily weighted towards carcinogenesis and immune system development, and research on the impact of DNA transaction in the nervous system has been surprisingly sparse. Thus, there has typically been no well-developed forum for sharing of ideas or fostering interactions among students, fellows and field leaders with interests in DNA transactions as they specifically relate to the brain. The need for a conference integrating DNA repair, genome stability and nervous system homeostasis has been addressed by the commencement of an international "Genome Dynamics in the Nervous System" conference series. In this application, we propose a meeting that integrates basic processes of DNA damage signaling and repair and clinical aspects of neurological and neurodegenerative disease. The program is designed to bring together leading scientists with primary interests in DNA damage signaling together with those working in specific related neurodegenerative disease areas as means for integrating these fields. It is anticipated that this will generate insights into how normal processes of genome maintenance in the brain contribute to the prevention of a wide range of diseases. The nervous system poses a particular challenge in terms of clinical intervention, as the neuropathology often arises during nervous system development.

描述（由申请人提供）：对基因毒性应激的反应是神经系统发育的先决条件。多种DNA修复或DNA损伤反应因子的突变可导致以明显神经病理学为特征的人类疾病。在许多这些综合征中，神经系统成分是该疾病最有害的方面之一。尽管基因组完整性在神经系统中很重要，但却明显缺乏一系列集中探讨DNA损伤反应在神经系统中的作用的会议。虽然被清楚地认为是神经系统疾病的关键因素，但在科学会议上对DNA修复和DNA损伤信号的讨论却严重偏重于致癌和免疫系统发育，而关于DNA交易在神经系统中的影响的研究却出奇地少。因此，在对DNA交易感兴趣的学生、研究员和领域领导者之间，通常没有一个成熟的论坛来分享想法或促进互动，因为DNA交易与大脑特别相关。国际“神经系统基因组动力学”系列会议的开始已经解决了整合DNA修复，基因组稳定性和神经系统稳态的会议需求。在本应用中，我们建议召开一次会议，整合DNA损伤信号传导和修复的基本过程以及神经和神经退行性疾病的临床方面。该计划旨在将主要研究DNA损伤信号的顶尖科学家与特定相关神经退行性疾病领域的科学家聚集在一起，作为整合这些领域的手段。预计这将有助于深入了解大脑中基因组维持的正常过程如何有助于预防各种疾病。神经系统在临床干预方面提出了一个特殊的挑战，因为神经病理经常在神经系统发育过程中出现。